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Showing 3 results for khadem erfan
Dr Sherko Nasseri, Dr Sako Mirzaee, Dr Zakaria Vahabzadeh, Dr Mohammad Bagher Khadem Erfan, Dr Bahram Nikkhoo, Dr Zhila Bahrami Rad, Dr Negar Zamani, Dr Fardin Fathi,
Volume 27, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2022)
Abstract
Background and Aim: Fam83h Protein is a non-secretory protein that interacts with Casein Kinase1Alpha1(CSNK1A1) through its N-terminal.
Materials and Methods: In this study, the C-terminal domains of Fam83h in human and mouse were modeled using the I-TASER software for prediction of protein structure and function. The molecular dynamics (MD) simulations were performed by GROMACS version 5.0.2 to investigate their temporal behavior. FEL analysis was done for each model after MD. Protein-protein docking was done by PIPER to investigate the interaction of Fam83h C-terminal with cytoskeletal keratins5 as a cellular keratin model.
Results: The results showed that the human protein is more stable and compact than the mouse protein. Assessment of the interaction between the C-terminal of the mouse Fam83h and Keratin-5 proteins showed the residues Arg378, Pro391, Ser663, Glu710, Arg923 in mouse Fam83h protein made hydrogen bonds with Leu474, Arg417, Tyr453, Glu 397, Gln 396 and Glu 390 of the chain A and B of mouse keratin-5, respectively. Human Fam83h and keratin 5 form hydrogen bonds via residues of Thr433, His447 and Arg477 and Leu473, Gly476, Glu420 and Arg407.
Conclusion: According to the previous experimental reports, Fam83h can interact with keratin cytoskeleton and has a role in cancer progression. It can be concluded that Fam83h protein can directly interact with keratin filaments through its C-terminal. Therefore, our hypothesis based on in-silico study is: non-sense mutation in C-terminal of Fam83h protein may lead to truncated protein and subsequently disruption of keratin cytoskeleton bundling which can be regarded as a mechanism involved in cancer progression.
Dr Yahya Maroufi, Dr Ghasem Zamini, Dr Mohammad Bagher Khadem Erfan, Dr Bijan Nori, Dr Ashkan Faridi,
Volume 30, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2025)
Abstract
Abstract
Background and Aim: Toxocariasis is a parasitic disease caused by the round worm Toxocara. Dogs are the definitive host for this parasite and, also several pathogens could be transmitted by dogs to humans as zoonotic diseases.
Materials and Methods: This study was conducted in 2016-2017 with 111 stool samples collected from stray dogs in Sanandaj. Sanandaj was divided into five parts: north, south, east, west, and center. The coordinates of the sampling site were determined on the map by online GPS and ArcGIS software. Samples were examined by formalin-ether concentration method. The rate of toxocariasis in dogs was obtained by descriptive statistical methods and expressed as a percentage.
Results: Out of 111 samples, 7 samples (6.306%) were positive. Four positive cases were related to the samples collected in the spring, one was related to the samples collected in the winter, and two were related to the samples collected in the autumn.
Conclusion: The contamination rate of Toxocara in stray dogs in Sanandaj is lower than in comparison to the other areas studied in Iran. Given the high number of stray dogs in Sanandaj, it is essential to conduct further eco-epidemiological studies with a focus on dog-borne diseases to determine the importance of stray dogs in transmitting these diseases to humans.
Dr Fares Bahrami, Dr Erfan Sherifi, Dr Yahya Maroufi, Dr Khaled Rahmani, Dr Mohammad Bagher Khadem Erfan, Dr Ghasem Zamini,
Volume 30, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2025)
Abstract
Background and Aim: Intestinal parasitic infections are among the major health problems worldwide. The symptoms and signs of these infections can range from mild to severe depending on the type of parasite and host conditions. This study aimed to assess the prevalence of intestinal protozoan infections among HIV+/AIDS individuals and evaluate the impact of certain demographic factors on these infections in Kurdistan Province.
Materials and Methods: In this cross-sectional study, 161 stool samples were collected using a convenience sampling method from HIV+/AIDS individuals in Kurdistan Province. After obtaining informed consent, demographic information such as age, gender, residence, drinking water source, and history of animal contact was collected through questionnaires for each patient. All samples were examined using direct smear, formalin-ether concentration, and Ziehl–Neelsen staining methods. The obtained data were analyzed using independent t-tests and Fisher's exact test.
Results: Of all samples analyzed, 53 cases (32.9%) were infected with one or more intestinal protozoa. Among the identified protozoa, Blastocystis (19.3%) had the highest prevalence, while Iodamoeba butschlii (1.9%) had the lowest. The overall frequency of protozoan infections did not significantly affect the demographic variables studied (P > 0.05). However, untreated drinking water was significantly associated with Cryptosporidium infection (P = 0.02).
Conclusion: Intestinal protozoan infections are prevalent among HIV+/AIDS individuals in Kurdistan Province. Therefore, the results of this study provide crucial information for healthcare providers to facilitate accurate diagnosis and design intervention programs to improve patient care and reduce the prevalence of these infections in the region.
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