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ABSTRACT Background and Aim: Survivin is a new member of inhibitor of apoptosis protein family (IAP) that plays an important role in the regulation of cell cycle and inhibition of apoptosis. Distinct expression of this gene in tumoral cells versus normal cells introduces it as the fourth major transcriptome in cancers. Thyroid carcinoma is the most common endocrine malignancy. Considering the highly heterogeneous nature of tumoral and non-tumoral thyroid nodules from the pathological viewpoint and also in regard to the absence of appropriate molecular markers, extensive efforts have been made to find a specific molecular tumor marker for diagnosis of thyroid tumors. Studies have been demonstrated that the expression pattern of survivin and its splice variants was different in cancerous tissues compared to normal tissues. In this study we evaluated expression of survivin-3b and survivin-3α, the novel survivin splice variants, as diagnostic markers for thyroid cancer. Materials and Method: This was a descriptive study. 77 thyroid specimens including 49 tumoral, 14 non-tumoral and 14 tumor margin samples were collected and expression of survivin-3b ands-3α was investigated by hemi-nested RT-PCR method. Results: Tumoral samples showed the highest expression of survivin-3b and survivin-3α and the lowest expression was detected in the specimens of tumor margins. Conclusion: In this study we demonstrated the expression of survivin-3b and survivin-3α in thyroid tumors for the first time. In conclusion significant expression of survivin-3b and survivin-3α splice variants in tumoral cells shows their roles in thyroid cancer progression and their efficiency as molecular markers for detection and classification of tumoral and non-tumoral thyroid nodules. Key words: Thyroid cancer, Survivin-3b، Survivin-3α, Splice variant, Hemi-nested RT-PCR Received: Aug 15, 2011 Accepted: Aug 30, 2012

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ABSTRACT Background and Aim: It is possible to explain the great discrepancy in the personality and psychopathology of patients with borderline personality disorder (BPD), partly, on the basis of differences in their profiles of personality, psychopathology, intellectual and emotional state. The aim of the current study was to assess these items in the patients with BPD. Material and Method: This was a descriptive-comparative study. Among the patients with diagnosis of BPD referring to Sanandaj health centers,30 accepted to participate in this study. They were assessed by use of MCMI-III, emotional state questionnaire, and The WAIS-R. The results were compared with those of their matched, non-clinical group. SPSS software was used for data processing and data were analyzed by profile analysis and one way ANOVA. Results: Profile analysis showed significant differences between the groups in all of the tests. Comparison of the single scales showed differences in a wide range of variables of personality, intellectual and emotional state. Conclusion: The results indicated an important role for the emotional elements in the development of personality disorders and also similarity of many of the clinical symptoms in these patients. Intellectual elements are also useful for explaining a fundamental part of the symptoms of BPD. These variables seem essential for understanding cognitive, affective and behavioral aspects of the patients with BPD. Keywords: Borderline personality disorder, Psychopathology, Personality, Intelligence. Received: Aug 14, 2012 Accepted: Apr 24, 2013 Conflict of interest: None declared