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Showing 7 results for Fallah
Dr Maziyeh Moghadam, Dr Soraya Rashidzadeh, Dr Narges Shamsalizadeh, Badieh Fallahi, Volume 19, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2014)
Abstract
Background and Aim: Medical students experience a high level of stress, with potential adverse consequences on their academic performance. Stressors cannot be modified in numerous cases but students' abilities to cope with stressors should be upgraded.
In this study, we investigated the effect of stress management training (As part of the Life Skills Curriculum in Kurdistan University of Medical Sciences) on perceived stress, coping style in medical college students and also persistence of the effect of training.
Material and method: This was a quasi-experimental study (before and after). The sample size was 35 medical students and included all of the second semester medical students. Sampling method was census. Stress management training included four two-hour sessions for four consecutive weeks. Assessment was carried out by use of Perceived Stress Scale (PSS-14) and Coping Inventory for Stressful Situations (CISS-21) in four steps (before, immediately, 3 and 6 months after classes). Collected data were entered into SPSS17 software and analyzed by paired t-tests., ANOVA and Tukey post hoc test.
Result: Before training, the mean value for perceived stress among students was 33.42 which decreased to 32.70, 31.50 and 29.22, after one, three and six months after training, respectively.
We found significant differences in perceived stress only between the stages conducted before training and six months after training. (P-Value: 0.012).
The dominant style of copping with stress in all periods was that of problem oriented but changes in a variety of styles in different periods were not significant.
Conclusion: In this study, reduced perceived stress can be related to the training, but the role of confounding factors should be kept in mind.
Lack of change in the students´ coping style after training can be attributed to short-term training and defective contents of the training.
It seems that other factors such as students’ level of education and compulsory training can interfere with the results of this study.
Therefore, further studies are required to carry out alterations in the life skill curriculum in Kurdistan University of medical sciences.
Key word: Medical student, life skills, Stress management, Perceived stress, Copping style with stress.
Received: May 11, 2013 Accepted: Jun 10, 2014
Latifeh Mohammadpour, Dr Mohammad Sadegh Fallah, Dr Fatemeh Keshavarzi, Dr Siroos Zeinali, Dr Bayazeed Ghaderi, Dr Azad Fattahy Rad, Dr Reza Akramipour, Sara Azadmehr, Volume 20, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2015)
Abstract
Background and Aim: Alpha Thalassemia is an autosomal recessive genetic disease by reduced or absent synthesis of alpha globin polypeptide chains. One of the severe forms of disease with 3 alpha globin genes inactivation is H disease. In this study genotype of H disease was assessed in some patients with blood abnormalities referred to hospitals of Kermanshah and Kurdistan provinces. Materials and method: In this descriptive research, 110 patients with microcytic and hypochromic anemia were recruited. Based on CBC and hemoglobin electrophoresis tests in patients before blood transfusion or their parents, alpha thalassemia was diagnosed. DNA was extracted by salting out method. The common deletions, alpha globin point mutations and direct sequencing were investigated using multiplex PCR and Sanger methods respectively. Results: In twelve alpha thalassemia patients, it has been shown the deletion mutations of --Med in 5 patients (20.8%), -α3.7 in 4 patients (6.6%) and -α20.5 in 3 patients (12.5%) and also point mutations polyA1 in 3 patients (12.5%),-αcd59 in 2 patients (8.3%) and -αIVSI (-5nt) in 2 patients (8.3%). In 4 cases deletion (-α/--) and in 3 cases (40%) non-deletion H disease (--/ααT) were diagnosed. Two cases showed point mutation of ααT/ααT. Two patients were blood-transfusion dependent. The first one who received regular blood monthly, showed --Med/αcd59 genotype. The second one with -α20.5/-α3.7 genotype received blood occasionally. In 7 patient’s enlargement of spleen was observed and in 3 patients splenectomy was performed earlier. Conclusion: The results showed the genetic diversity in alpha-globin and the importance of point mutations in the H disease. However, further study should be done to determine the accurate genotype and phenotype relationship and to diagnose of H disease in prenatal cases. Keywords: Alpha Thalassemia, H disease, Kurdistan, Kermanshah. Received: Jul 16, 2014 Accepted: Feb 7, 2015
Arezoo Darabi, Dr Fatemeh Keshavarzi, Bahareh Sedaghatikhayat, Pezhman Salehifar, Mahboobeh Masoudifar, Dr Azad Fattahy Rad, Dr Siroos Zeinali, Dr Mohammad Sadegh Fallah, Volume 20, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2015)
Abstract
Background and Aim: Beta-thalassemia is a common autosomal recessive disorder of hemoglobin synthesis. About 200 mutations of beta globin genes have been detected .This study was performed to determine beta globin gene mutations in blood transfusion dependent patients in Kurdistan Province hospitals from June 2012 to April 2014 .
Material and Methods: This descriptive study included sixthy eight blood transfusion dependent patients with beta- thalassemia major who had referred to Kurdistan Province hospital.Patients and their parents completed our questionnaires. Based on CBC and hemoglobin electrophoresis results diagnosis of beta thalassemia was made. 5 ml blood was obtained from every participant and DNA was extracted by using standard salting out method. Then we investigated beta globin gene mutations by ARMS-PCR method and DNA sequencing.
Results: The most prevalent mutations were IVS-II-1 in 30 allels (22.5%), Fr8-9(+G) in 22 allels (15.94%), IVS-I-1 in 13 allels (9.42%) and C36/37 in 11 allels (7.97%). Among 138 allels, types of mutations in 42 allels of assessed 138 allels remained unknown.
Conclusion: The results of this study were compatible with those of another study performed in Sanandaj in 2003, but in our study, mutation of C36/37 was more prevalent.
Keywords: Beta thalassemia, ARMS-PCR, Kurdistan
Received: Sep 28, 2014 Accepted: Jul 6, 2015
Hamid Hosseini, Zia Fallahmohammadi, Volume 25, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2020)
Abstract
Background and Aim: Multiple Sclerosis is a chronic inflammatory disease with unknown etiology in the nervous system. However, exercise routinely for these patients is beneficial, but the effect of pretreatment swimming exercise in this disease has not been fixed. Therefore, the aim of these study was to investigate pretreatment effect of swimming exercise on NGF levels in female Lewis rats with experimental autoimmune encephalomyelitis.
Materials and Methods: This experimental in vitro study was conducted on female Lewis rats. In this study, animals were randomly divided into 4 groups (each group 5), including healthy control, EAE control, healthy swimming and EAE swimming. The training protocol included swimming exercise 1 hour/day, 5 days/week for six weeks.
Results: This study shows that NGF levels in EAE swimming group were significantly increased compared to the same controls (P= 0.006). Also the weight of EAE swimming training group significantly increased compared with control (P=0.001).
Conclusion: According to these findings, concluded that pretreatment with sub-chronic swimming exercise, through increased levels of NGF, is effective in inhibiting EAE. Hence, perhaps, the protocol used in this study to enhance the protection of nerve cells in the brain tissue of MS Risk Factors and ultimately recommended to promote brain health.
Hossein Fallah, Behnaz Danesh, Beydolah Shahouzehi, Abbas Mohammadi, Volume 26, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2021)
Abstract
Background and Aim: Insulin resistance is a pathological condition in which cells fail to respond normally to insulin. The most important cause of insulin resistance is abdominal obesity. Increased abdominal fat increases the amount of free fatty acids and decreases adiponectin, which directly affects insulin signaling. Due to the role of Quercus infectoria in lowering blood sugar, we investigated the mechanism of action and the effect of its aqueous extract on insulin resistance in insulin-resistant Rats.
Materials and Methods: The animals were fed fructose-rich or normal food for six weeks. At the end of six weeks, the animals were divided into 4 groups including receiving plant extracts, pioglitazone, control, and normal food, and then treated for 2 weeks. At the end of the treatment period serum Glucose, triglyceride, and cholesterol levels were measured by autoanalyzer; Insulin and adiponectin levels were measured by ELISA; plasma free fatty acids were measured by gas chromatography, and HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) index was calculated by the formula. A one-way ANOVA test was used for statistical analysis.
Results: In the Quercus infectoria group, the concentrations of glucose (129.3±6.8 mg/dl), triglyceride (79.8±5.1mg/dl), insulin (31.2±6.32pmol/L) and HOMA-IR (1.6±0.32) significantly decreased compared to the control group with glucose (187.5± 15.9 mg/dl), Triglyceride (217.6±18.5 mg/dl), Insulin (137.6±34.2 pmol/L) and HOMA-IR (9.7±2.13) decreased. The concentration of total free fatty acids and adiponectin did not change.
Conclusion: This study showed the beneficial effects of aqueous extracts of Quercus infectoria on reducing insulin resistance in insulin-resistant rats.
Beydolah Shahouzehi, Mrs. Saeedeh Moinaldini, Mr. Mostafa Allahyari, Dr. Hossein Fallah, Volume 28, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2023)
Abstract
Background and Aim: Diabetes mellitus is a metabolic disorder with an increasing prevalence in the world. Obesity plays a pivotal role in increasing the risk of diabetes, metabolic syndrome, hypertension and cardiovascular diseases. Obesity dependent mild-inflammation leads to an imbalance in the secretion of adipokines and thereby reduces insulin sensitivity. The TLR family plays an important role in these inflammatory pathways, and therefore inhibition of IRAK, as a key mediator of the pathway, plays a role in inhibiting inflammation and insulin resistance. In this study we investigated the effect of this inhibitor on the expression levels of PPAR-γ and GLUT.4, which are involved in insulin sensitivity.
Materials and Methods: In this study, male C57BL/6J mice were used for induction of insulin resistance. Mice were divided into 6 groups including standard diet, high fat diet, high fat diet + solvent, high fat diet + pioglitazone, high fat diet + IRAK inhibitor and high fat diet + combination of pioglitazone-IRAK inhibitor. At the end of the study, the mice were killed and expression levels of GLUT4 and TPPAR-γ in muscle tissue of the mice were measured by Real Time PCR.
Results: This study showed that pioglitazone, IRAK inhibitor, and the combination of IRAK inhibitor- Pioglitazone increased PPAR-γ expression in muscle tissue, but IRAK inhibitor unlike pioglitazone had no effect on GLUT.4 expression.
Conclusion: The results of this study suggested that insulin sensitizing effects of IRAK inhibitor may be induced by increasing PPAR-γ expression level.
Sahar Nawrozi, Afshin Bahmani, Sairan Nili, Arezoo Fallahi, Volume 29, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2024)
Abstract
Background and Aim:Considering the global spread of the coronavirus and its adverse consequences, adoption of preventive behavior stratgies is a suitable solution to reduce the sequelae by this disease. Considering the effectiveness of the developed parallel process model in changing behavior, this study aimed to investigate the effect of the extended parallel process model on adoption of preventive behavior aginst coronavirus infection in young women.
Materials and Methods: This intervention (experimental) study was conducted in 2022. Using a multi-stage sampling method 222 young women were entered into the study. Data were collected using a researcher's questionnaire based on the extended parallel process model. The educational intervention was performed through 4 virtual sessions. Three months after the last session, the participants completed the questionnaire again. Using SPSS software version 26, data were analyzed by descriptive and analytical statistical tests.
Results: The results of the study showed that after the educational intervention, the mean scores of the model and behavior structures showed a significant difference between the two test and control groups (P<0.05). Before the training, 4.5% of the participants of the intervention group were in the risk control process, and after the training intervention, this figured reached 20.7%, which was statistically significant. After the educational intervention we found significant difference between the control and intervention groups in terms of the risk control process or fear control process (P=0.049).
Conclusion: Use of the developed parallel process model is effective in adopting preventive behaviors against the coronavirus in young women.
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