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Background and Aim: A low level of adiponectin have a great effect on the breast cancer incidence and increase in adiponectin after a period of exercise training may be associated with changes in insulin resistance. Therefore, the present study aimed to investigate the effect of 12 weeks of selected Pilates exercise training on serum adiponectin level and insulin resistance in female survivors of breast cancer and its role in prevention of the recurrence.

Material and Methods: 27 breast cancer survivors (mean age 44.11±6.19 years old, BMI 29.24±4.92 kg/m²) were selected based on our inclusion criteria and randomly divided into experimental (n=14) and control (n=13) groups. The experimental group participated in a 12 weeks of selected Pilates exercise training (three session per week). During this period, the control group did not participate in any exercise training program. Data were analyzed using paired and independent t-test.

Results: Serum adiponectin level and VO₂max significantly increased, but insulin level, insulin resistance and body fat percentage significantly decreased and the FBS level had no significant change after selected Pilates exercise training (P<0.05).

Conclusion: Considering the increase in adiponectin level and decrease in insulin resistance after selected Pilates exercise training, it seems participation of the breast cancer survivors in Pilates exercise training can prevent breast cancer recurrence.

Keywords: Breast cancer, Adiponectin, Insulin resistance, Pilates

 

Received: Aug 16, 2015      Accepted: Sep 12, 2015

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Background and Aim: The purpose of this study was to investigate the effect of endurance training intensity (low, moderate and high) on the expression of skeletal muscle ATGL protein and serum levels of insulin and glucose in male diabetic rats.
Material and Method: 40 streptozotocin induced diabetic male Wistar rats were randomly assigned to five groups of eight, including low (DL , moderate (DM) and high intensity (DH) endurance training diabetic groups, diabetic control group (D), and healthy control group (Con). Three sessions of endurance training with low intensity (DL( equivalent to 5-8 m / min, moderate intensity (DM) equivalent to 17-14 m / min and high intensity (DH) equivalent to 25-22 m / min were performed every week for eight weeks. The relative expression of ATGL protein was measured with western blot technique. Serum insulin and glucose levels were measured by ELISA method. To determine the difference between the groups we used one way ANOVA test.
Result: The results showed a significant difference in the expression of ATGL between the control and training groups (with low, moderate and high intensity) (p=0.0002). This difference was significant between DH and D (p=0.0049), DH and DL (p = 0.0053) and also between DH and DM (P = 0.0136) groups. Serum glucose levels were also significantly different between the DH group with the groups D (p = 0.002) and DL (p = 0.039), also, the DM group with groups D (p = 0.0018) and DL (p = 0.0165). There was a significant difference in the amount of insulin in the DH group compared to the groups DL (p = 0.011), D (p = 0.0002), and the DM group with D (p = 0.014).
 
Conclusion: Moderate and high intensity endurance training can to some extent compensate for diabetes-induced reduction in the expression of ATGL protein and cause reduction of serum insulin and glucose levels in diabetic rats. It seems higher intensity of endurance training can lead to greater increase in expression of ATGL in diabetic rats.
Keywords: Diabetes, ATGL, Endurance training intensity, Insulin, Glucose.
 
Received: Oct 17, 2017     Accepted: Jan 29, 2018