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Citation Indices from GS

AllSince 2020
Citations102755683
h-index3925
i10-index268141

 

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Central Library of Kurdistan University of Medical Sciences
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Showing 2 results for Angaji

Sahar Daraei, Dr Seyed Abdolhamid Angaji, Saeed Morovvati, Dr Mohammad Tahmaseb, Neda Asari,
Volume 20, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2015)
Abstract

Background and Aim: Abortion is spontaneous termination of pregnancy before the 20th week. Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses. There are several known risk factors associated with recurrent miscarriages, including genetic, endocrine, autoimmune, anatomical. Causes of recurrent miscarriages in 50% of the cases remain unexplained. It has been hypothesized that genetic polymorphism in estrogen receptor genes would be associated with recurrent miscarriages.

Material and Materials: This study included 80 patients with a history of three or more consecutive unexplained abortions and 80 women with at least 2 live births without any miscarriage. Then we investigated estrogen receptor gene polymorphism in the participants by allele specific polymerase chain reaction (AS-PCR) method.

Results: The frequencies of rs1256149 polymorphisms among the women with recurrent abortions and also the women in the control group were 80% and 62.5 % respectively. There was a significant difference in the genotype frequencies between RPL and the control groups (p=0.028).

Conclusion: These findings indicated that estrogen receptor polymorphism can be regarded as a genetic marker for recurrent spontaneous abortions.

Keyword: Estrogen receptor gene, Polymorphisms of 1082G/A, Recurrent

Background and Aim: Abortion is spontaneous termination of pregnancy before the 20th week. Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses. There are several known risk factors associated with recurrent miscarriages, including genetic, endocrine, autoimmune, anatomical. Causes of recurrent miscarriages in 50% of the cases remain unexplained. It has been hypothesized that genetic polymorphism in estrogen receptor genes would be associated with recurrent miscarriages.

Material and Materials: This study included 80 patients with a history of three or more consecutive unexplained abortions and 80 women with at least 2 live births without any miscarriage. Then we investigated estrogen receptor gene polymorphism in the participants by allele specific polymerase chain reaction (AS-PCR) method.

Results: The frequencies of rs1256149 polymorphisms among the women with recurrent abortions and also the women in the control group were 80% and 62.5 % respectively. There was a significant difference in the genotype frequencies between RPL and the control groups (p=0.028).

Conclusion: These findings indicated that estrogen receptor polymorphism can be regarded as a genetic marker for recurrent spontaneous abortions.

Keyword: Estrogen receptor gene, Polymorphisms of 1082G/A, Recurrent pregnancy loss.

 

Received: Jan 13, 2015      Accepted: May 31, 2015pregnancy loss.

Received: Jan 13, 2015      Accepted: May 31, 2015


Shabnam Khazraei, Seyed Abdolhamid Angaji, Behnaz Beikzadeh, Mitra Salehi, Raheleh Roudi, Behzad Narouie,
Volume 29, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2024)
Abstract

Background and Aim: Prostate Cancer (PC) is one of the most common cancers and the second leading cause of death in Iranian men. Several factors such as age, endogenous hormone balance, genetic factors and environmental factors are involved in PC incidence. The aim of this study was to investigate the association of rs351855 and rs1983891 polymorphisms with prostate cancer risk in Iranian population.
Materials and Methods: In this case-control study 185 peripheral blood samples were taken from 101 patients with prostate cancer and 84 healthy individuals. For SNP genotyping in each sample, Tetra-ARMs PCR method was used.
Results: According to the multi-stage method, 58 individuals were selected in the first stage. p-value<0.4 was considered significant. In relation to rs351855, there was a significant difference between the case and control groups (P<0.16), but, there was no significant difference between the groups in regard to rs1983891 (P<0.62). Therefore, rs1983891 was eliminated at this stage. In the second stage, all samples (184 samples) were analyzed in relation to rs351855 at a significance level of P<0.05. A significant difference was observed between the two groups of case and control in relation to rs351855 polymorphism in all samples (P<0.00). In this study, allelic and genotypic frequencies were investigated in multiplicative and additive genetic models. Our data showed a significant relationship between the multiplicative model allele (A) and the risk of prostate cancer, also the data indicated that the additive model AA vs GG and AG vs GG were associated with PC. On the other hand, this polymorphism was associated with all three levels of PSA and Gleason score.
Conclusion: In the present study rs351855 polymorphism was associated with the risk of prostate cancer in Iran, on the contrary, rs1983891 polymorphism was not associated with prostate cancer risk. rs351855 may be considered as a potential biomarker for the screening of prostate cancer.

 

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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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