[Home ] [Archive]   [ فارسی ]  
:: Volume 13, Issue 4 (Scientific Journal of Kurdistan University of Medical Science 2009) ::
SJKU 2009, 13(4): 30-36 Back to browse issues page
The study of analgesic effect of hydroalcoholic extract of Artemisia herba alba in acute and chronic models of pain in male rats
Hosein Sadeghifard , Parvin Zareian Dr 1
1- , Zareian2008@gmail.com
Abstract:   (8450 Views)
Backround and Aim: In the present time, analgesic and anti-inflammatory drugs such as nonseroidal anti-inflammatory drugs and opioid compounds are used for the releif of pain, but due to their side effects and economical issues, the significance of research on finding analgesic drugs with less side effects and their ability to substitute these synthetic drugs and substituting newer analgesic compounds is obvious. There is very little information about physiologic effects of Artemisia herba alba, one of species of Herba alba family. In the present study the possible analgesic effects of hydroalcoholic extract of this plant were investigated in chemical and thermal models of nociception in rats. Material and Methods: In this experimental study, percolation method was used for extraction. Specified amounts of dried extract were dissolved in twin to produce desired concentration. The extract were used orally or injected intraperitoneally and analgesic activity was assessed with two methods, Tail flick and Formalin test. In addition, anti nociceptive effect of this plant was compared with sodium salicylate as standard drug. Results: The plant extract significantly increased tail flick latency in tail flick test and decreased significantly pain perception in both phases of formalin test. The anti-nociception effect of herba alba was dose dependent. Conclusion: These data confirm peripheral and central antianalgesic effect of this plant. Key words: Acute pain, chronic pain, Artemisia herba alba- formalin test, tail flick test Conflict of Interest: Nill Received: August 5, 2008 Accepted: December 26, 2008
Keywords: Acute pain, chronic pain, Artemisia herba alba- formalin test, tail flick test
Full-Text [PDF 139 kb]   (1795 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/05/3
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sadeghifard H, Zareian P. The study of analgesic effect of hydroalcoholic extract of Artemisia herba alba in acute and chronic models of pain in male rats. SJKU. 2009; 13 (4) :30-36
URL: http://sjku.muk.ac.ir/article-1-98-en.html


Volume 13, Issue 4 (Scientific Journal of Kurdistan University of Medical Science 2009) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 3781