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Study the relation of serum vitamin D levels and iron indices in response to treatment of idiopathic granulomatous mastitis in patients referred to the Breast Clinic of Kurdistan University of Medical Sciences in 2021
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Mohamad Raman Moloudi1    , Hassan Moaiery2 , Saed Hosseini2 |
1- Kurdistan University of Medical Sciences , x.moloudi@gmail.com
2- Kurdistan University of Medical Sciences |
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Abstract: (127 Views) |
Background and Aim
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease with an unclear etiology and heterogeneous treatment outcomes. Given the immunomodulatory role of vitamin D and the involvement of iron metabolism in inflammatory conditions, this study aimed to evaluate the association between baseline serum vitamin D levels, iron parameters, and treatment outcomes in patients with IGM.
Materials and Methods
In this cross-sectional study, 34 women with pathologically confirmed IGM who were referred to the Breast Clinic of Kurdistan University of Medical Sciences between April 2021 and March 2022 were enrolled. Baseline serum levels of 25-hydroxyvitamin D, iron, ferritin, total iron-binding capacity (TIBC), and hematological parameters were measured prior to treatment initiation. Treatment response was classified as complete recovery, partial recovery, or recurrence based on clinical examination and ultrasonographic findings. Comparisons between groups were performed using one-way ANOVA.
Results
The mean age of participants was 34.9 ± 6.4 years. Complete recovery was observed in 52.9% of patients, partial recovery in 32.4%, and recurrence in 14.7%. No statistically significant association was found between baseline serum vitamin D levels and treatment outcomes (p > 0.05). Similarly, serum iron, ferritin, TIBC, hemoglobin, hematocrit, MCV, and MCH showed no significant differences among outcome groups.
Conclusion
Baseline serum vitamin D levels and iron-related parameters were not significantly associated with treatment outcomes in patients with idiopathic granulomatous mastitis. These findings suggest that routine measurement of these biomarkers at diagnosis may have limited prognostic value. Given the small sample size, results should be interpreted with caution, and further prospective studies with larger cohorts are warranted. |
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| Keywords: Idiopathic granulomatous mastitis, Vitamin D, Iron parameters, Treatment outcome |
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Type of Study: Original Research |
Subject:
Medicine - General Surgery
Received: 2025/09/28 | Accepted: 2026/02/18
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