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:: Volume 12, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2008) ::
SJKU 2008, 12(4): 40-44 Back to browse issues page
Prognostic value of serum T-lymphocyte cytokines for prediction of early acute rejection of renal transplants
A Ghafari Dr, A Eishi Dr, E Rahimi Dr , L Fakhri
Abstract:  

  ABSTRACT

 Background and Aim: Acute rejection is one of the most important complications after renal transplantation which influences transplant prognosis and survival. This study was conducted to determine the prognostic value of Th1/ Th2 cytokines in acute renal rejection (AR).

 Material and Methods: This was a cross-sectional study and included 60 kidney transplant recipients (40 male, mean age 38.82), who had received their transplants from live donors. Serum levels of Th-1 dependent cytokines [interleukin- (IL) 2 and interferon-gamma] and Th-2 dependent cytokines (IL-4, IL-10) were measured on the day before, 7th and 14th days post transplantation using ELISA. All the patients received Immunosupressive agents including cyclosporine, mychofenolate mofetile and prednisolon. Acute rejection was defined as a more than 50 percent rise in serum creatinin in the first 20 days after transplantation. Data were introduced into SPSS soft ware and analyzed by means of independent T-test.

 Results: Among 60 patients, 40 were male. The mean age of the patients were 38.82 years. In our study we diagnosed twelve cases of AR (20% of the cases). There was no significant relation between the serum levels of IL2, IL4, IL10 and IFNδ in the patients with acute rejection of the transplant and those without.

Conclusion: These data showed that there is no correlation between Th1/ Th2 serum cytokines profile and early AR episodes in kidney transplantation and these cytokines can not be used as prognostic factors in acute renal rejection
Keywords: Key words: kidney transplantation, Transplant rejection, T-lymphocytes.
Full-Text [PDF 109 kb]      
Type of Study: Research | Subject: General
Received: 2009/04/14
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Volume 12, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2008) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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