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Serum vitamin D levels and acute respiratory distress syndrome in premature neonates
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Salman Daliri1    , Mahboobeh Mohammadi2 , Mahtab Hajian3 , Zeinab Mohammadi3 , Marzieh Mohammadi Kordkhayli4 , Nazanin Rezaei5 |
1- .Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran.
2- School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. , m_m361kord@yahoo.com
3- Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
4- Bahar Hospital, Shahroud University of Medical Sciences, Shahroud, Iran.
5- Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. |
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Abstract: (192 Views) |
Abstract
Background and Aim: Acute respiratory distress syndrome is one of the main causes of death in neonates. Studies have shown that 25-hydroxy vitamin D3 [25(OH) D3] has a significant effect on fetal lung growth and can be related to acute respiratory distress. The present study was conducted to investigate the relationship between serum 25 OH Vitamin D3 levels and acute respiratory distress syndrome in premature neonates.
Materials and Methods: This study was conducted as a case-control study in which 105 premature neonates with acute respiratory distress syndrome were selected as the case group and 35 premature neonates without acute respiratory distress syndrome were selected as the control group from the neonatal intensive care unit of Bahar Hospital (Shahroud, Iran) in 2019 and 2021. Then, serum 25 OH Vitamin D3 levels of the neonates and mothers were measured 24 hours after birth.
Results: the average serum 25 OH Vitamin D3 level in neonates and mothers was 19.53±10.71 and 28.57±15.26 ng/ml, respectively. The average serum level of 25 OH Vitamin D3 in neonates of the case group was 15.27±7.08 ng/ml; in the control group, it was 32.34±9.53 ng/ml. The average duration of hospitalization in neonates with ARDS with 25 OH Vitamin D3 deficiency was longer than that of neonates with normal 25 OH Vitamin D3. Also, in ARDS neonates with 25 OH Vitamin D3 deficiency, 12.5%, 71.9%, and 78.1% needed ventilators, surfactant, and Continuous positive airway pressure, respectively.
Conclusions: Based on the findings, neonates with ARDS were more deficient and had insufficient levels of 25 OH Vitamin D3 than healthy neonates. Also, 25 OH Vitamin D3 deficiency in sick neonates led to an increase in the need for clinical interventions including surfactant administration, mechanical ventilation, and Continuous positive airway pressure. |
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| Keywords: 25-hydroxy vitamin D3 [25(OH) D3], premature neonates, respiratory distress syndrome |
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Full-Text [PDF 424 kb]
(30 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - Pediatric
Received: 2024/02/17 | Accepted: 2025/06/9 | Published: 2026/04/11
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