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Antibacterial Effect of Mixed Oxidant Solution on Methicillin-resistant Staphylococcus aureus (MRSA)
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Fariba Karimi1    , َAhmad Ahmadi2 , Ghane Zandi3 , Abbas Aghaei4 , Abbas Ahmadi5 , Farid Zandi6 |
1- Kurdistan University of Medical Sciences
2- University of Kurdistan
3- Science and Technology Park of Kurdistan
4- Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences
5- Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences
6- Kurdistan University of Medical Sciences, Dehgolan, Iran & Roonak Beautiful Morning Star Company, Science and Technology Park of Kurdistan, , zandifarid@gmail.com |
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Abstract: (38 Views) |
ABSTRACT
Background and Aim: Nosocomial infections are one of the important causes of annual mortality in the world. Many of these infections caused by drug-resistant bacteria have failed the treatment strategy of such infections. One of the causes of nosocomial infections is methicillin-resistant bacteria (MRSA). Eradication of these, bacteria carrying the drug resistance gene, using disinfectants can reduce nosocomial infections caused by MRSAs and other bacteria carrying the resistance gene. The aim of this study was to investigate antibacterial effect of mixed oxidant solution produced by disinfectant generator on methicillin-resistant Staphylococcus aureus (MRSA) isolates.
Materials and Methods: In this study, tested disinfectant solution was made by Mixed Oxidant Generator. Also, methicillin-resistant Staphylococcus aureus (MRSA) was prepared from 90 clinical samples of teaching hospitals of Kurdistan University of Medical Sciences. Then the samples cultured by swap method. Two phenotypic and genotypic methods were used to confirm staphylococci carrying the mecA gene.
Results: The results show that the Mixed Oxidant solution produced from 2% saline contains the highest concentration of oxidant gradients, so that diluting 1:4 of this solution (Mixed Oxidant solution) eliminates MRSA isolates. In contrast, the Mixed Oxidant produced from 0.1% saline has a low concentration of mixing oxidant gradients, as it was the lowest antibacterial effect to inhibit the growth of MRSAs in direct concentration.
Conclusion: Due to the remarkable effectiveness, health and economic efficiency of the produced oxidant solution, it is recommended as a suitable large-scale disinfectant for various disinfection purposes is recommended.
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| Keywords: Mixed oxidant, Staphylococcus aureus, MRSA, Disinfection, Hypochlorous acid |
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Type of Study: Original Research |
Subject:
Microbiology
Received: 2023/11/3 | Accepted: 2024/09/29
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