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A novel therapeutic strategy for Parkinson's disease based on the gut microbiota: a review article
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Romina Kardan1   , Mohsen Nazari2 , Jaber Hemmati2 , Amjad Ahmadi 3, Mahtab Ashab4 |
1- Shahid Sadougi University of Medical Sciences, Yazd
2- Department of Microbiology, School of Medicine, Hammdan University of Medical Sciences, Hamedan, Iran
3- Department of Microbiology, School of Medicine, Hammdan University of Medical Sciences, Hamedan, Iran , microbiology90@gmail.com
4- Payame Noor University of Pardis Branch |
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Abstract: (147 Views) |
| Background and Aim: The gut microbiota, which is now recognized as an important organ of the human body, can have an impact on various neurological outcomes such as cognition, learning, and memory. In addition, the gut microbiota can regulate brain growth and behavior, which plays a role in different neurological disorders. In this study, we aim to investigate the relationship between gut microbiota and Parkinson's disease and to highlight appropriate microbiota-based therapeutic approaches for Parkinson's disease Materials and Methods: In this research, we searched the articles based on the keywords of "Parkinson's", "microbiota", "microbiome", "gut microbiota", "gut microbiome", "fecal microbiota", "fecal microbiome", "probiotic", and "gut-brain axis" from all databases such as ISI web of science, PubMed, Science direct, Google scholar, SID and Scopus were extracted and reviewed. The inclusion criteria of study included English and Persian language articles, original articles and articles with open access, and the exclusion criteria of study included articles other than English and Persian, articles without open access, meta-analysis and reviews. Results: Fecal microbiota transplant and probiotics laid the groundwork for identifying the mechanisms underlying the ability of the gut microbiota to influence a host's brain and behavior. It could help in preventing or early diagnosis of Parkinson's disease possibly through some peripheral biomarkers. If this hypothesis is valid and that gut microbiota is involved in Parkinson's disease etiology, we might be looking at a new treatment regimen for this disease focused on dietary and pharmacological interventions to maintain healthy gut microbiota. Conclusion: Recent studies have also shown that patients with Parkinson's disease have a disruption in gut microbiota balance (dysbiosis), but the exact role of this in causing the neurological disorder is still unknown. However, new approaches based on gut microbiota can be developed to prevent and treat neurological disorders such as Parkinson's. |
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| Keywords: Microbiome, Gut-brain axis, Parkinson's, Probiotics |
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Type of Study: Review |
Subject:
Microbiology
Received: 2023/06/30 | Accepted: 2023/11/7
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