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Assessment of the Correlation between Postictal Suppression and Therapeutic Effects of Electroconvulsive Therapy
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Mahdie Ershad Langroudi1    , Narges Shams-Alizadeh2 , Azad Maroufi3 , Khaled Rahmani4 , Farzane Karimian5 |
1- Private Clinic, Lahijan, Iran
2- Department of Psychiatry, Neuroscience Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Department of Psychiatry, Neuroscience Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran , azadmaroufi@yahoo.com
4- Department of Epidemiology, Kurdistan University of Medical Sciences, Sanandaj, Iran
5- Private Clinic, Sanandaj, Iran |
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Abstract: (32 Views) |
Background and Aim: The use of electroconvulsive therapy (ECT) is one of the most effective methods for treating psychiatric disorders. Recently, postictal suppression in electroencephalography (EEG) has gained attention as a predictive factor for treatment success. The aim of this study was to investigate the relationship between postictal suppression of brain waves and the therapeutic effects of ECT.
Materials and Methods: This cross-sectional (descriptive-analytical) study was performed on 64 patients with depressive disorder, bipolar disorder, and schizophrenia, who were referred to the ECT ward of Qods Hospital in Sanandaj during 2020-2021. The improvement in symptoms before and after the completion of ECT was measured using standard questionnaires, Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), and Positive and Negative Syndrome Scale (PANSS). Additionally, EEG indices, including polyspike phase amplitude, polyspike phase duration, slow-wave phase amplitude, slow-wave phase duration, regularity, stereotypy, and postictal suppression were measured. The relationship between symptom improvement and EEG indices, including the level of postictal suppression was analyzed using one-way ANOVA and Pearson correlation coefficient.
Results: Out of 64 patients studied, 19 (29.7%) had schizophrenia, 24 (37.5%) had depression, and 21 (32.8%) had mania. The results showed a relationship between postictal suppression and symptom improvement in patients with depression (P = 0.002), schizophrenia (P = 0.001) and bipolar disorder (P = 0.001). There was also a direct relationship between paroxetine use and postictal suppression (P <0.001). According to the findings, risperidone use had an inverse relationship with postictal suppression (P = 0.010).
Conclusion: Based on the findings of the present study, postictal suppression can be considered a predictor variable for symptom improvement following ECT in depressive disorders, mania, and schizophrenia. |
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| Keywords: Postictal suppression, ECT, EEG, Depressive disorder, Schizophrenia, Bipolar disorder |
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Type of Study: Applicable |
Subject:
Psychiatric
Received: 2022/04/20 | Accepted: 2022/06/15
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