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Citations98565244
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Central Library of Kurdistan University of Medical Sciences
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:: Volume 28, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2023) ::
SJKU 2023, 28(2): 28-39 Back to browse issues page
Alpha-Pinene Effect on the Improvement of Working and Spatial memory in Rats
Paria Hashemi 1, Helia Rahmani2 , Mohammad Raman Moloudi3 , Zakaria Vahabzadeh4 , Esmael Izadpanah5
1- Ph.D of Physiology, Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. , pr.hashemi@yahoo.com
2- MSc student, Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
3- Associate Professor of Physiology, Neurosciences Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
4- Associate Professor of Clinical Biochemistry, Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran & Associate Professor of Clinical Biochemistry, Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
5- Associate Professor of Physiology, Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Abstract:   (1569 Views)
Background and Aim: Oxidative stress is an important factor in the development of memory and learning disorder which can cause neuronal damage in the hippocampus. Alpha-pinene is a polyphenolic compound from the terpene family that has shown important anti-inflammatory, anti-anxiety, antioxidant and neuroprotective effects in the central nervous system and can affect memory. The aim of the present study was to investigate the effect of alpha-pinene on the improvement of working and spatial memory in rats. 
Materials and Methods: In this study, 24 male rats were randomly divided into 3 groups: control and 2 alpha-pinene groups (5 and 10 mg/kg IP) for 3 weeks. Spatial and working memories were assessed by Morris water maze and Y maze, respectively. Then, malondialdehyde level and total antioxidant capacity in hippocampal tissue were measured. Data were analyzed using one-way analysis of variance and Tukey's post hoc test.
Results: The percentage of alternation in the Y maze increased in the group which had received 10 mg/kg alpha-pinene group compared to those in the control group and the group which had received 5 mg/kg alpha-pinene. The time spent in the target area at the dose of 10 mg/kg of alpha-pinene showed a significant increase compared to that in the control group, but there was no significant difference among the groups in terms of the time to reach the target platform. Alpha-pinene at the dose of 10 mg/kg decreased the level of malondialdehyde in hippocampal tissue compared to the control group, but no significant difference was observed between the groups in terms of total antioxidant capacity.
Conclusion: Alpha-pinene increased spatial and working memory performance in rats. One of the possible mechanisms of memory improvement in the present study could be due to the reduction of malondialdehyde in the hippocampal tissue, as one of the important indicators of oxidative stress in the central nervous system.



 
Keywords: Oxidative stress, Alpha-pinene, Working memory, Spatial memory, Malondialdehyde, Total antioxidant capacity
Full-Text [PDF 844 kb]   (471 Downloads)    
Type of Study: Original Research | Subject: Physiology and neurosciences
Received: 2022/04/19 | Accepted: 2022/07/19 | Published: 2023/05/28
References
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15. Ciobica A, Olteanu Z, Padurariu M, Hritcu L. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. J Physiol Biochem. 2012;68(1):59-69. [DOI:10.1007/s13105-011-0119-x] [PMID]
16. Nikfarjam M, Bahmani M, Naimi A. Native medicinal plants of Iran effective on Memory and Learning: A Review. Int J Pharmtech Res. 2016;9(5):466-73.
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18. Rahnama S, Rabiei Z, Alibabaei Z, Mokhtari S, Rafieian-Kopaei M, Deris F. Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurol Sci. 2015;36(4):553-60. [DOI:10.1007/s10072-014-1991-2] [PMID]
19. Him A, Ozbek H, Turel I, Oner AC. Antinociceptive activity of alpha-pinene and fenchone. Pharmacologyonline. 2008;3:363-9.
20. Türkez H, Aydın E. In vitro assessment of cytogenetic and oxidative effects of α-pinene. Toxicol Ind Health. 2016;32(1):168-76. [DOI:10.1177/0748233713498456] [PMID]
21. Bertouche S, Tomao V, Ruiz K, Hellal A, Boutekedjiret C, Chemat F. First approach on moisture determination in food products using alpha-pinene as an alternative solvent for Dean-Stark distillation. Food Chem. 2012;134(1):602-5. [DOI:10.1016/j.foodchem.2012.02.158]
22. Saeedipour S, Rafieirad M. Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats. KAUMS Journal (FEYZ). 2020;24(3):253-45.
23. Ho C-L, Tseng Y-H, Wang EI-C, Liao P-C, Chou J-C, Lin C-N, et al. Composition, antioxidant and antimicrobial activities of the seed essential oil of Calocedrus formosana from Taiwan. Nat Prod Commun. 2011;6(1):1934578X1100600132. [DOI:10.1177/1934578X1100600132]
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25. Lee G-Y, Lee C, Park GH, Jang J-H. Amelioration of Scopolamine-Induced Learning and Memory Impairment by Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases. Evid Based Complement Alternat Med. Available from: vol. 2017, Article ID 4926815, 9 pages, 2017. [DOI:10.1155/2017/4926815] [PMID] []
27. Goudarzi S, Rafieirad M. Evaluating the effect of α-pinene on motor activity, avoidance memory and lipid peroxidation in animal model of Parkinson disease in adult male rats. RJP. 2017;4(2):53-63.
28. Khan‐Mohammadi‐Khorrami MK, Asle‐Rousta M, Rahnema M, Amini R. Neuroprotective effect of alpha‐pinene is mediated by suppression of the TNF‐α/NF‐κB pathway in Alzheimer's disease rat model. J Biochem Mol Toxicol. 2022;36(5):e23006. doi: 10.1002/jbt.23006. [DOI:10.1002/jbt.23006] [PMID]
29. Malik J, Karan M, Dogra R. Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism. Pharm Biol. 2017;55(1):980-90. [DOI:10.1080/13880209.2017.1285945] [PMID] []
30. Tashakori-Miyanroudi M, Ramazi S, Hashemi P, Nazari-Serenjeh M, Baluchnejadmojarad T, Roghani M. Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy. J Mol Neurosci. 2022; 72: 1224-1233. [DOI:10.1007/s12031-022-01999-8] [PMID]
31. Tashakori-Miyanroudi M, Souresrafil A, Hashemi P, Ehsanzadeh SJ, Farrahizadeh M, Behroozi Z. Prevalence of depression, anxiety, and psychological distress in patients with epilepsy during COVID-19: A systematic review. Epilepsy Behav. 2021;125:108410. [DOI:10.1016/j.yebeh.2021.108410] [PMID] []
32. Salim S. Oxidative stress and psychological disorders. Curr Neuropharmacol. 2014;12(2):140-7. [DOI:10.2174/1570159X11666131120230309] [PMID] []
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34. Huang Y, Coupland NJ, Lebel RM, Carter R, Seres P, Wilman AH, et al. Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study. Biol Psychiatry. 2013;74(1):62-8. [DOI:10.1016/j.biopsych.2013.01.005] [PMID]
35. Huang T-T, Zou Y, Corniola R, editors. Oxidative stress and adult neurogenesis-effects of radiation and superoxide dismutase deficiency. Semin Cell Dev Biol. 2012; 23(7):738-744. [DOI:10.1016/j.semcdb.2012.04.003] [PMID] []
36. Guan Z-z. Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer's disease. Acta Pharmacol Sin. 2008;29(7):773-80. [DOI:10.1111/j.1745-7254.2008.00819.x] [PMID]
37. Kamat PK, Kalani A, Rai S, Swarnkar S, Tota S, Nath C, et al. Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies. Mol Neurobiol. 2016;53(1):648-61. [DOI:10.1007/s12035-014-9053-6] [PMID] []
38. Mohsenzadeh A, Ahmadipour S, Ahmadipour S, Asadi-Samani M. Iran's medicinal plants effective on fever in children: A review. Pharm Lett. 2016;8(1):129-34.
39. Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, et al. Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy. IBRO Rep. 2020;9:102-14. [DOI:10.1016/j.ibror.2020.07.007] [PMID] []
40. Allenspach M, Steuer C. α-Pinene: A never-ending story. Phytochemistry. 2021;190:112857. [DOI:10.1016/j.phytochem.2021.112857] [PMID]
41. Ahmadi-kanali R, Abbasnejad M, Esmaeili-Mahani S, Pourrahimi AM, Kooshki R. Effects of Intra-hippocampal Administration of Alpha-pinene on Learning and Memory Performances in Adult Male Rats. JMUMS. 2021;31(200):26-37.
42. Bartsch T, Arzy S. Human memory: insights into hippocampal networks in epilepsy. Brain. 2014;137(7):1856-7. [DOI:10.1093/brain/awu125] [PMID]
43. Lee JL. Memory reconsolidation mediates the strengthening of memories by additional learning. Nat Neurosci. 2008;11(11):1264-6. [DOI:10.1038/nn.2205] [PMID]
44. Barry DN, Maguire EA. Remote memory and the hippocampus: A constructive critique. Trends Cogn Sci. 2019;23(2):128-42. [DOI:10.1016/j.tics.2018.11.005] [PMID]
45. Bartsch T. The clinical neurobiology of the hippocampus: An integrative view: Oxford University Press; 2012: 214-9 [DOI:10.1093/acprof:oso/9780199592388.001.0001]
46. Hashemi P, Babaei JF, Vazifekhah S, Nikbakht F. Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway. Iran J Basic Med Sci. 2019; 22(7): 752-8.
47. Vazifehkhah S, Ali MK, Babae JF, Hashemi P, Alireza MS, Nikbakht F. Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats. Life Sci. 2020;257:11806. [DOI:10.1016/j.lfs.2020.118066] [PMID]
48. Coras R, Pauli E, Li J, Schwarz M, Rössler K, Buchfelder M, et al. Differential influence of hippocampal subfields to memory formation: insights from patients with temporal lobe epilepsy. Brain. 2014;137(7):1945-57. [DOI:10.1093/brain/awu100] [PMID]
49. Panegyres P. The contribution of the study of neurodegenerative disorders to the understanding of human memory. Qjm. 2004;97(9):555-67. [DOI:10.1093/qjmed/hch096] [PMID]
50. Hernandez-Rapp J, Rainone S, Hébert SS. MicroRNAs underlying memory deficits in neurodegenerative disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2017;73:79-86. [DOI:10.1016/j.pnpbp.2016.04.011] [PMID]
51. Alzoubi KH, Khabour OF, Salah HA, Rashid BEA. The combined effect of sleep deprivation and Western diet on spatial learning and memory: role of BDNF and oxidative stress. J Mol Neurosci. 2013 May;50(1):124-33. [DOI:10.1007/s12031-012-9881-7] [PMID]
52. Shin E-J, Jeong JH, Chung YH, Kim W-K, Ko K-H, Bach J-H, et al. Role of oxidative stress in epileptic seizures. Neurochem Int. 2011;59(2):122-37. [DOI:10.1016/j.neuint.2011.03.025] [PMID] []
53. Baluchnejadmojarad T, Roghani M. Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat. J Mol Neurosci. 2013;49(1):194-201. [DOI:10.1007/s12031-012-9886-2] [PMID]
54. Fukui K, Onodera K, Shinkai T, Suzuki S, Urano S. Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann N Y Acad Sci. 2001;928(1):168-75. [DOI:10.1111/j.1749-6632.2001.tb05646.x] [PMID]
55. Saki K, Bahmani M, Rafieian-Kopaei M, Hassanzadazar H, Dehghan K, Bahmani F, et al. The most common native medicinal plants used for psychiatric and neurological disorders in Urmia city, northwest of Iran. Asian Pac J Trop Dis. 2014;4:S895-S901. [DOI:10.1016/S2222-1808(14)60754-4]
56. Ciobica A, Olteanu Z, Padurariu M, Hritcu L. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. J Physiol Biochem. 2012;68(1):59-69. [DOI:10.1007/s13105-011-0119-x] [PMID]
57. Nikfarjam M, Bahmani M, Naimi A. Native medicinal plants of Iran effective on Memory and Learning: A Review. Int J Pharmtech Res. 2016;9(5):466-73.
58. Nikbakht F, Khadem Y, Haghani S, Hoseininia H, Sadat AM, Heshemi P, et al. Protective role of apigenin against Aβ 25-35 toxicity via inhibition of mitochondrial cytochrome c release. Basic Clin Neurosci. 2019;10(6):557-66. [DOI:10.32598/bcn.9.10.385] [PMID] []
59. Rahnama S, Rabiei Z, Alibabaei Z, Mokhtari S, Rafieian-Kopaei M, Deris F. Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurol Sci. 2015;36(4):553-60. [DOI:10.1007/s10072-014-1991-2] [PMID]
60. Him A, Ozbek H, Turel I, Oner AC. Antinociceptive activity of alpha-pinene and fenchone. Pharmacologyonline. 2008;3:363-9.
61. Türkez H, Aydın E. In vitro assessment of cytogenetic and oxidative effects of α-pinene. Toxicol Ind Health. 2016;32(1):168-76. [DOI:10.1177/0748233713498456] [PMID]
62. Bertouche S, Tomao V, Ruiz K, Hellal A, Boutekedjiret C, Chemat F. First approach on moisture determination in food products using alpha-pinene as an alternative solvent for Dean-Stark distillation. Food Chem. 2012;134(1):602-5. [DOI:10.1016/j.foodchem.2012.02.158]
63. Saeedipour S, Rafieirad M. Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats. KAUMS Journal (FEYZ). 2020;24(3):253-45.
64. Ho C-L, Tseng Y-H, Wang EI-C, Liao P-C, Chou J-C, Lin C-N, et al. Composition, antioxidant and antimicrobial activities of the seed essential oil of Calocedrus formosana from Taiwan. Nat Prod Commun. 2011;6(1):1934578X1100600132. [DOI:10.1177/1934578X1100600132]
65. Kim D-S, Lee H-J, Jeon Y-D, Han Y-H, Kee J-Y, Kim H-J, et al. Alpha-pinene exhibits anti-inflammatory activity through the suppression of MAPKs and the NF-κB pathway in mouse peritoneal macrophages. Am J Chin Med. 2015;43(04):731-42. [DOI:10.1142/S0192415X15500457] [PMID]
66. Lee G-Y, Lee C, Park GH, Jang J-H. Amelioration of Scopolamine-Induced Learning and Memory Impairment by Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases. Evid Based Complement Alternat Med. Available from: vol. 2017, Article ID 4926815, 9 pages, 2017. https://doi.org/10.1155/2017/4926815 [DOI:10.1155/2017/4926815.] [PMID] []
67. Goudarzi S, Rafieirad M. Evaluating the effect of α-pinene on motor activity, avoidance memory and lipid peroxidation in animal model of Parkinson disease in adult male rats. RJP. 2017;4(2):53-63.
68. Khan‐Mohammadi‐Khorrami MK, Asle‐Rousta M, Rahnema M, Amini R. Neuroprotective effect of alpha‐pinene is mediated by suppression of the TNF‐α/NF‐κB pathway in Alzheimer's disease rat model. J Biochem Mol Toxicol. 2022;36(5):e23006. doi: 10.1002/jbt.23006. [DOI:10.1002/jbt.23006] [PMID]
69. Malik J, Karan M, Dogra R. Ameliorating effect of Celastrus paniculatus standardized extract and its fractions on 3-nitropropionic acid induced neuronal damage in rats: possible antioxidant mechanism. Pharm Biol. 2017;55(1):980-90. [DOI:10.1080/13880209.2017.1285945] [PMID] []
70. Tashakori-Miyanroudi M, Ramazi S, Hashemi P, Nazari-Serenjeh M, Baluchnejadmojarad T, Roghani M. Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy. J Mol Neurosci. 2022; 72: 1224-1233. [DOI:10.1007/s12031-022-01999-8] [PMID]
71. Tashakori-Miyanroudi M, Souresrafil A, Hashemi P, Ehsanzadeh SJ, Farrahizadeh M, Behroozi Z. Prevalence of depression, anxiety, and psychological distress in patients with epilepsy during COVID-19: A systematic review. Epilepsy Behav. 2021;125:108410. [DOI:10.1016/j.yebeh.2021.108410] [PMID] []
72. Salim S. Oxidative stress and psychological disorders. Curr Neuropharmacol. 2014;12(2):140-7. [DOI:10.2174/1570159X11666131120230309] [PMID] []
73. Salim S. Oxidative stress and the central nervous system. J Pharmacol Exp Ther. 2017; 360(1):201-5. [DOI:10.1124/jpet.116.237503] [PMID] []
74. Huang Y, Coupland NJ, Lebel RM, Carter R, Seres P, Wilman AH, et al. Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study. Biol Psychiatry. 2013;74(1):62-8. [DOI:10.1016/j.biopsych.2013.01.005] [PMID]
75. Huang T-T, Zou Y, Corniola R, editors. Oxidative stress and adult neurogenesis-effects of radiation and superoxide dismutase deficiency. Semin Cell Dev Biol. 2012; 23(7):738-744. [DOI:10.1016/j.semcdb.2012.04.003] [PMID] []
76. Guan Z-z. Cross-talk between oxidative stress and modifications of cholinergic and glutaminergic receptors in the pathogenesis of Alzheimer's disease. Acta Pharmacol Sin. 2008;29(7):773-80. [DOI:10.1111/j.1745-7254.2008.00819.x] [PMID]
77. Kamat PK, Kalani A, Rai S, Swarnkar S, Tota S, Nath C, et al. Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies. Mol Neurobiol. 2016;53(1):648-61. [DOI:10.1007/s12035-014-9053-6] [PMID] []
78. Mohsenzadeh A, Ahmadipour S, Ahmadipour S, Asadi-Samani M. Iran's medicinal plants effective on fever in children: A review. Pharm Lett. 2016;8(1):129-34.
79. Ueno H, Shimada A, Suemitsu S, Murakami S, Kitamura N, Wani K, et al. Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy. IBRO Rep. 2020;9:102-14. [DOI:10.1016/j.ibror.2020.07.007] [PMID] []
80. Allenspach M, Steuer C. α-Pinene: A never-ending story. Phytochemistry. 2021;190:112857. [DOI:10.1016/j.phytochem.2021.112857] [PMID]
81. Ahmadi-kanali R, Abbasnejad M, Esmaeili-Mahani S, Pourrahimi AM, Kooshki R. Effects of Intra-hippocampal Administration of Alpha-pinene on Learning and Memory Performances in Adult Male Rats. JMUMS. 2021;31(200):26-37.
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Hashemi P, Rahmani H, Moloudi M R, Vahabzadeh Z, Izadpanah E. Alpha-Pinene Effect on the Improvement of Working and Spatial memory in Rats. SJKU 2023; 28 (2) :28-39
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