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:: Volume 13, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2008) ::
SJKU 2008, 13(2): 42-49 Back to browse issues page
Effects of Permethrin on sexual behaviour and plasma concentrations of pituitary-gonadal hormones in adult male NMRI mice
Jalal Solati Dr 1, Ramin Hadjikhani Dr2, Rohollah Tude zaeem Dr
1- Instructor , solati@kiau.ac.ir
2- Assistant Professor
Abstract:  
ABSTRACT Background and Aim: Pyrethroids are commonly used as insecticides for both household and agricultural purposes, and recently have been shown to have detrimental effects on endocrine system. Permethrin is a type I pyrethroid which is used widely in Iran. In the present study the effects of permethrin on sexual behaviour and plasma level of PG (pituitary-gonadal) hormones of adult male mice were investigated. Material and Methods: Mice received daily Intra peritoneal injection of permethrin (10, 15, 20 mg/kg) for 5 weeks. Using receptive females, permethrin-treated male mice exhibited reduced sexual behavior (i.e. decrease in the number of sniffing, following, mounting and mating). Results: The concentrations of plasma testosterone, LH and FSH were measured by means of ELISA method. Serum testosterone levels were reduced significantly (p<0.05) in the experimental group versus control group, whereas FSH and LH values were not altered significantly. Conclusion: The results of this study indicate permethrin can have detrimental effects on plasma testosterone level and sexual behavior. In regard to considerable use of this insecticide in Iran, it’s necessary to restrain its use and extent of human contact to prevent hazards of this insecticide on human body tissues. Key words: Insecticide, Permethrin, Sexual hormones, sexual behavior. Conflict of Interest: Nill Received: January 14, 2007 Accepted: July 13, 2008
Keywords: Insecticide, Permethrin, Sexual hormones, sexual behavior
Full-Text [PDF 129 kb]      
Type of Study: Research | Subject: General
Received: 2009/04/11
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Volume 13, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2008) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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