:: Volume 25, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2020) ::
SJKU 2020, 25(1): 1-11 Back to browse issues page
Investigating the Protective Effect of an Interval Training on Neutrophilic Factors of BDNF and CDNF in Rats Fed with High-fat Foods
Mohammad reza Asad1 , Soroor Hedayatnejad2 , Ali Barzegari 3, Mahbobeh Gholizadeh ahangari2
1- Department of physical education and sport, Payame Noor University, Tehran, Iran.
2- Department of physical education and sport, Payame Noor University, Tehran, Iran
3- Department of physical education and sport, Payame Noor University, Tehran, Iran , ali_barzegari@pnu.ac.ir
Abstract:   (634 Views)
Background and Aim: Exercise targets the secretion of brain-derived neurotrophic factors and has a major impact on the overall health of the brain. The present study aimed to investigate the protective effect of a period of interval training on neutrophilic factors of BDNF and CDNF in rats fed with high-fat foods.
Materials and Methods: In this experimental study, 42 male Wistar rats were randomly divided into 3 groups with same number: normal nutrition, high fat diet, and high fat diet + interval exercise. Interval exercises were performed in the first 3 weeks with low intensity, moderate intensity in week 4, and week of 5-8th at high intensity and 5 days in per week for 8 weeks. After the end of the eighth week, the rats were killed and the levels of the indices studied were evaluated by ELISA assay kits. One-way ANOVA and Bonferroni test were used to analyze of the data.
Results: The results showed that after a high-fat diet, there was a significant decrease in plasma levels of BDNF (P = 0.001) and CDNF (P = 0.001) compared to control group. On the other hand, after a period of interval exercise and nutrition, a significant increase was observed in BDNF levels (P= 0.001, P= 0.002) and CDNF (P= 0.001, P= 0.003) respectively, Compared to control and high fat diet groups.
Conclusion: These results may indicate the positive role of this type of exercise in preventing and neutralizing the disadvantages of high-fat diet, metabolic diseases, and as well as maintain of brain health.
Keywords: BDNF, CDNF, Full-fat diet, Interval training, Rat
Full-Text [PDF 535 kb]   (304 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/12/19 | Accepted: 2019/10/8 | Published: 2020/03/21


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Volume 25, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2020) Back to browse issues page