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Analgesic effect of Jasminum sambac hydro alcoholic extract in rats: role of the GABAergic and opioidergic pathways
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Omid Abdollahi   1, Mohammad Raman Moloudi2 , Dara Dastan3 , Katayoon Hassanzadeh4 , Esmael Izadpanah5 |
1- Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2- Neurosciences Research Center. Kurdistan University of Medical Sciences, Sanandaj, Iran.
3- Plants and Natural Products Research Center, Hamedan University of Medical Sciences and Health Services, Hamadan, Iran.
4- Department of Physiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
5- Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran |
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Abstract: (3794 Views) |
Background and Aim: There are several reports about analgesic, anti-depressant, anti-inflammatory, antiseptic, sedative, and anti-spasmodic effects of Jasminum sambac. The aim of this study was to investigate the analgesic effects of Jasminum sambac hydroalcoholic extract and determine the role of GABAergic and opioidergic pathways in rat model by a plantar device.
Material and Methods: Wistar male rats were randomly divided into six groups (n=6) including control, the groups treated with hydroalcoholic extract of Jasminum Sambac (100, 200, 400, mg/kg, ip) and the groups which received the most effective dose of the extract in addition to naloxone or flumazenil. The analgesic effect was assessed by plantar device after 30, 60 and 90 min of the injections.
Results: Our results showed that injection of hydroalcoholic extract of Jasminum sambac (200 mg/kg, ip) increased significantly the time delay in response to thermal pain inducing effect at 30, 60 and 90 (P <0.05) min after injection in the experimental groups compared to that in the control group. While, addition of naloxone, prevented analgesic effect of the extract at all three times (P <0.05). This pattern of reduction of extract analgesic effect was significant only 60 min after concomitant administration of the extract with flumazenil.
Conclusion: The results indicated the analgesic effect of Jasminumsambac extract. Considering the preventive effect of naloxone on the analgesia produced by Jasminum sambac, opioidergic pathway seems to be dominant in the development of Jasminum sambac analgesic effect.
Keyword: Hydroalcoholic extract of Jasminum sambac, Analgesic effect, Opioidergic pathways.
Received: Dec 31, 2017 Accepted: May 22, 2018 |
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| Keywords: Hydroalcoholic extract of Jasminum sambac, Analgesic effect, Opioidergic pathways. |
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Full-Text [PDF 258 kb]
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Type of Study: Original Research |
Subject:
General
Received: 2018/07/31 | Accepted: 2018/07/31 | Published: 2018/07/31
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