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:: Volume 15, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2011) ::
SJKU 2011, 15(4): 1-9 Back to browse issues page
Evaluation of the effect of intra cerebroventricular administration of CCPA on reduction of tolerance to the analgesic effect of morphine in rat
Mohammad Charkhpour Dr1, Alireza Parvizpour Dr1, Farid Ebrahimi 2, Esmael Izadpanah Dr3, Kambiz Hasanzadeh Dr 4
1- Assistan Professor Tabriz University of Medical Sciences
2- Tabriz University of Medical Sciences
3- Kurdistan University of Medical Sciences
4- Assistan Professor Kurdistan University of Medical Sciences , kambizhassanzadeh@gmail.com
Abstract:   (15461 Views)
ABSTRACT Background and aim: Continuous or long term use of opiate drugs may cause tolerance to the analgesic effect of these drugs, which limits the therapeutic efficacy of these drugs. In this study we evaluated the effects of central administration of 2-chloro-N6-cyclopentyladenosine (CCPA), a selective A1 receptor agonist, on morphine-induced tolerance in rats. Materials and Methods: Different groups of rats received daily intracerebroventricular (ICV) morphine (10 mg/kg, ip) in combination with saline 5 μl/rat, or intracerebroventricular (icv) CCPA (20, 40, 80 μg/5 μl/rat). Nociception was assessed by use of a hotplate apparatus (55±0.5°C). Using a hot-plate device, the pain inducing effect was recorded when the rat licked its hind paw or jumped. Results: Results showed that different doses of CCPA (20, 40, 80 μg/5 μl/rat, icv) delayed the tolerance to the analgesic effect of morphine for 4, 8, and 10 days respectively. In addition, our results showed that CCPA increased the total analgesic effect of morphine. Conclusion: We found that intracerebroventricular administration of CCPA, A1 selective agonists, prevented morphine-induced tolerance to the analgesic effect in rat. Key words: CCPA, morphine, tolerance, adenosine receptor Conflict of Interest: Nill Received: July 31, 2010 Accepted: Dec 20, 2010
Keywords: CCPA, morphine, tolerance, adenosine receptor
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Type of Study: Research | Subject: General
Received: 2011/02/22 | Accepted: 2015/01/10 | Published: 2015/01/10
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Volume 15, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2011) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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