:: Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(2): 70-80 Back to browse issues page
The protective effects of Tanacetum parthenium extract on CCl4-induced myocardium injury in rats
Mohammad Mazani Dr1, Yavar Mahmoodzadeh 2, Lotfollah Rezagolizadeh Dr * 3
1- Associated Professor Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
2- Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
3- Assistant Professor Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran , reza34055@gmail.com
Abstract:   (174 Views)
Background and Aim: The aim of this study was to investigate the protective effects of Tanacetum parthenium extract (TPE) on lipid peroxidation and acute heart injury induced by carbon tetrachloride (CCl4) in rats.
Materials and Methods: In an experimental study, 30 male Wistar rats were divided into 5 groups (n=6). Two of the groups were normal and damage control groups, other 3 groups were damage groups treated with 40, 80 and 120 mg / kg of TPE for 14 days before being damaged by CCl4. At the end of the study we measured the activity of creatine kinase (CK-MB) isoenzyme and lactate dehydrogenase (LDH), total cholesterol (TC), HDL-C and LDL-C in serum, as well as the activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), and arylesterase (ARE) and malondialdehyde (MDA) concentration, as lipid peroxidation index, in myocardial homogenates.
Results: The results of this study showed that treatment with carbon tetrachloride significantly increased the levels of CK-MB, LDH, TC, LDL-C and MDA and decreased ARE, HDL-C, SOD and GPX (P <0.001) in a dose dependent manner.
Conclusion: The present study demonstrated that TPE can be considered as a substance with various potential effects such as antioxidant activity and cardioprotective effects.
Key words: Tanacetum parthenium, Carbon tetrachloride, Myocardium, Lipid peroxidation, Antioxidant.
Received: Sep 20, 2017     Accepted: Jan 30, 2018
Keywords: Tanacetum parthenium, Carbon tetrachloride, Myocardium, Lipid peroxidation, Antioxidant.
Full-Text [PDF 813 kb]   (104 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/05/31 | Accepted: 2018/05/31 | Published: 2018/05/31
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Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page