:: Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(2): 70-80 Back to browse issues page
The protective effects of Tanacetum parthenium extract on CCl4-induced myocardium injury in rats
Mohammad Mazani Dr1, Yavar Mahmoodzadeh 1, Lotfollah Rezagolizadeh Dr * 2
1- Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
2- Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran , reza34055@gmail.com
Abstract:   (782 Views)
Background and Aim: The aim of this study was to investigate the protective effects of Tanacetum parthenium extract (TPE) on lipid peroxidation and acute heart injury induced by carbon tetrachloride (CCl4) in rats.
Materials and Methods: In an experimental study, 30 male Wistar rats were divided into 5 groups (n=6). Two of the groups were normal and damage control groups, other 3 groups were damage groups treated with 40, 80 and 120 mg / kg of TPE for 14 days before being damaged by CCl4. At the end of the study we measured the activity of creatine kinase (CK-MB) isoenzyme and lactate dehydrogenase (LDH), total cholesterol (TC), HDL-C and LDL-C in serum, as well as the activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), and arylesterase (ARE) and malondialdehyde (MDA) concentration, as lipid peroxidation index, in myocardial homogenates.
Results: The results of this study showed that treatment with carbon tetrachloride significantly increased the levels of CK-MB, LDH, TC, LDL-C and MDA and decreased ARE, HDL-C, SOD and GPX (P <0.001) in a dose dependent manner.
Conclusion: The present study demonstrated that TPE can be considered as a substance with various potential effects such as antioxidant activity and cardioprotective effects.
Key words: Tanacetum parthenium, Carbon tetrachloride, Myocardium, Lipid peroxidation, Antioxidant.
 
Received: Sep 20, 2017     Accepted: Jan 30, 2018
Keywords: Tanacetum parthenium, Carbon tetrachloride, Myocardium, Lipid peroxidation, Antioxidant.
Full-Text [PDF 813 kb]   (276 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/05/31 | Accepted: 2018/05/31 | Published: 2018/05/31
References
1. 1. Singh U, Jialal I. Oxidative stress and atherosclerosis. Pathophysiology 2006; 13: 129-42. [DOI:10.1016/j.pathophys.2006.05.002]
2. Iliskovic N, Singal PK. Lipid lowering: an important factor in preventing adriamycin-induced heart failure. Am J Pathol 1997; 150: 7-27.
3. Singal PK, Li T, Kumar D, Danelisen I, Iliskovic N. Adriamycin-induced heart failure: mechanisms and modulation. Mol Cell Biochem 2000; 207: 77-86. [DOI:10.1023/A:1007094214460]
4. Sahreen S, Khan MR, Khan RA, Alkreathy HM. Protective effects of Carissa opaca fruits against CCl4-induced oxidative kidney lipid peroxidation and trauma in rat. Food Nutr Res 2015; 59.
5. Cheng N, Ren N, Gao H, Lei X, Zheng J, Cao W. Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl 4-induced acute liver damage in mice. Food Chem Toxicol 2013; 55: 234-40. [DOI:10.1016/j.fct.2012.11.022]
6. Eshaghi M, Zare S, Banihabib N, Nejati V, Farokhi F, Mikaili P. Cardioprotective effect of Cornus mas fruit extract against carbon tetrachloride induced-cardiotoxicity in albino rats. J Basic Appl Sci Res 2012; 2: 11106-14.
7. Aksoy L, Sözbilir NB. Effects of Matricaria chamomilla L. on lipid peroxidation, antioxidant enzyme systems, and key liver enzymes in CCl4-treated rats. Toxicol Environ Chem 2012; 94: 1780-8. [DOI:10.1080/02772248.2012.729837]
8. Sahreen S, Khan MR, Khan RA, Alkreathy HM. Cardioprotective role of leaves extracts of Carissa opaca against CCl 4 induced toxicity in rats. BMC Res Notes 2014; 7: 224. [DOI:10.1186/1756-0500-7-224]
9. Sharopov FS, Setzer WN, Isupov SJ, Wink M. Composition and bioactivity of the essential oil of Tanacetum parthenium from a wild population growing in Tajikistan. Am J Essent Oils Nat Prod 2015; 2: 32-4.
10. Mahmoodzadeh Y, Mazani M, Rezagholizadeh L, Abbaspour A, Zabihi E, Pourmohammad P. Effect of Tanacetum parthenium Extract on Total Antioxidant Capacity of Tissues Damaged by Carbon Tetrachloride in Rats. J Ardabil Univ Med Sci 2017; 16: 363-73. [In Persian]
11. Pareek A, Suthar M, Rathore GS, Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacogn Rev 2011; 5: 103-10. [DOI:10.4103/0973-7847.79105]
12. Barsby RW, Salan U, Knight DW, Hoult JR. Feverfew and vascular smooth muscle: extracts from fresh and dried plants show opposing pharmacological profiles, dependent upon sesquiterpene lactone content. Planta Medica 1993; 59: 20-5. [DOI:10.1055/s-2006-959596]
13. Heptinstall S, Groenewegen W, Spangenberg Pt, Lösche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988; 115: 447-9.
14. Chikezie PC, Amadikwa UA. Protective effect of Allium sativa extract against carbon tetrachloride- induced hepatic oxidative stress and hyperlipidemia in rats. Afr J Biotechnol 2014; 13: 1671-8. [DOI:10.5897/AJB2013.13338]
15. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
16. Furlong CE, Richter RJ, Seidel SL, Motulsky AG. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon. Am J Hum Genet 1988; 43: 230-8.
17. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-8. [DOI:10.1016/0003-2697(78)90342-1]
18. Abd El-mohsen Ali S, Hussein Abdelhafiz Abdelaziz D. The Protective Effect of Date Seeds on Nephrotoxicity Induced by Carbon Tetrachloride in Rats. Int J Pharm Sci Rev Res 2014; 26: 62-8.
19. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54. [DOI:10.1016/0003-2697(76)90527-3]
20. Sahreen S, Khan MR, Khan RA. Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl 4-induced damage in rat. BMC Complement Altern Med 2011; 11:48. [DOI:10.1186/1472-6882-11-48]
21. Williams CA, Harborne JB, Geiger H, Hoult JR. The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties. Phytochemistry 1999; 51: 417-23. [DOI:10.1016/S0031-9422(99)00021-7]
22. Shankar NG, Manavalan R, Venkappayya D, Raj CD. Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats. Food Chem Toxicol 2008; 46: 3182-5. [DOI:10.1016/j.fct.2008.07.010]
23. Marimuthu S, Adluri RS, Rajagopalan R, Menon VP. Protective role of ferulic acid on carbon tetrachloride-induced hyperlipidemia and histological alterations in experimental rats. J Basic Clin Physiol Pharmacol 2013; 24: 59-66. [DOI:10.1515/jbcpp-2012-0053]
24. Kamalakkannan N, Rukkumani R, Viswanathan P, Rajasekharan KN, Menon VP. Effect of curcumin and its analogue on lipids in carbon tetrachloride–induced hepatotoxicity: A comparative study. Pharm biol 2005; 43: 460-6. [DOI:10.1080/13880200590963880]
25. Mahmoodzadeh Y, Mazani M, Rezagholizadeh L. Hepatoprotective Effect of Methanolic Tanacetum Parthenium Extract on CCl4-Induced Liver Damage in Rats. Toxicol Rep 2017; 4: 455-62. [DOI:10.1016/j.toxrep.2017.08.003]
26. Nasir A, Abubakar MG, Shehu RA, Aliyu U, Toge BK. Hepatoprotective effect of the aqueous leaf extract of Andrographis paniculata Nees against carbon tetrachloride–induced hepatotoxicity in rats. Nig J Basic Appl Sci 2013; 21: 45-54. [DOI:10.4314/njbas.v21i1.7]
27. Abirami A, Nagarani G, Siddhuraju P. Hepatoprotective effect of leaf extracts from Citrus hystrix and C. maxima against paracetamol induced liver injury in rats. Food Science and Human Wellness 2015; 4: 35-41. [DOI:10.1016/j.fshw.2015.02.002]



XML   Persian Abstract   Print



Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page