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:: Volume 15, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2010) ::
SJKU 2010, 15(1): 87-95 Back to browse issues page
Corneal Neovascularization: Review Article
Kamran Mansouri 1, Ali Mostafaie Dr2, Hamid Reza Mohammadi-Motlagh , Yadollah Shakiba
1- , kmansouri@kums.ac.ir
2- Professor
Abstract:   (11290 Views)
ABSTRACT Corneal neovascularization occurs through inordinate wound healing after infection, injury or surgery. Neovascularization is formation of new vascular structures in the locations which had not already vessels. The two overlapping mechanisms including vasculogenesis and angiogenesis are probably involved in neovascularization process, and the last mechanism is more involved in tumor growth and corneal and retinal disorders. In fact, corneal neovascularization is a visual threatening status that usually occurs along with inflammatory or infectious disorders of the eye surface. The studies of angiogenesis-related cancer showed that there is a balance between angiogenic factors (such as VEGF and FGF) and antiangiogenic molecules (such as angiostatin, endostatin and pigment epithelium-derived factor EPDF) in cornea. Problems such as inflammation, infection, injury and lesions result in corneal neovascularization, which are due to stimulation of angiogenesis in this tissue. Corneal neovascularization may be influenced by matrix metalloproteinase (MMPs) and other proteolytic enzymes. The application of new medical and surgical therapies such as angiostatic steroids, non-steroidal anti inflammatory drugs, argon laser photocoagulation and photodynamic therapy (PDT) in animal models had been efficient to some extent for inhibition of corneal neovascularization. In this study we reviewed neovascularization-dependent corneal disorders and molecular processes involved in this disorder, and also their potential therapies. Key words: Corneal Neovascularization, Angiogenesis, Inflammation, Matrix Metalloproteinase Conflict of Interest: Nill Received: Dec 7, 2009 Accepted: March 5, 2010
Keywords: Corneal Neovascularization, Angiogenesis, Inflammation, Matrix Metalloproteinase
Full-Text [PDF 638 kb]   (1193 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/09/5
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Volume 15, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2010) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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