:: Volume 20, Issue 6 (Scientifis Journal of Kurdistan University of Medical Sciences 2016) ::
SJKU 2016, 20(6): 26-33 Back to browse issues page
Comparison of the effect of single and multiple-dose methotrexate therapy on tubal patency in women with ectopic pregnancy
Taravat Fakheri Dr, Nazanin Farshchian Dr, Mansour Rezaie Dr, Seyedeh Mozhgan Seyedzadeh Dr 1
1- , Sm.seyedzadeh@kums.ac.ir
Abstract:   (2824 Views)

Background and Aim: Ectopic pregnancy is one of the leading causes of death among the women of reproductive age. Injection of single or multiple doses of methotrexate can be used as a therapeutic approach. The aim of this study was to compare the effect of single and multiple-doses of methotrexate therapy on the tubal patency in women with ectopic pregnancy.

Material and Methods: This was an interventional study and included 80 patients with ectopic pregnancy who had been treated with a single dose or multiple doses of methotrexate. After 3 months of hospitalization and treatment, hysterosalpingography was conducted to assess tubal patency. Data were analyzed using SPSS version 21.

Results: The frequencies of ipsilateral tubal obstruction were 12 (30%) and 3 (7.5%) in the patients who had received multiple-doses of methotrexate and single-dose methotrexate respectively. Also, 33 (82.5%) patients in the single-dose methotrexate group and 18 (45%) patients in the multiple-dose methotrexate group did not have bilateral obstruction. There was a significant difference in the frequencies of tubal obstruction between the two groups treated with single and multiple doses of methotrexate (P<0.05).

Conclusion: The incidence of tubal obstruction in women with ectopic pregnancy was significantly lower in single-dose methotrexate group compared to multiple dose methotrexate groups.

Keywords: Ectopic pregnancy, Tubal obstruction, Single-dose methotrexate, Multiple dose methotrexates.

 

Received: Apr 28, 2015      Accepted: Nov 23, 2015

Keywords: Ectopic pregnancy, Tubal obstruction, Single-dose methotrexate, Multiple dose methotrexates.
Full-Text [PDF 151 kb]   (1017 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/02/8 | Accepted: 2016/02/8 | Published: 2016/02/8



XML   Persian Abstract   Print



Volume 20, Issue 6 (Scientifis Journal of Kurdistan University of Medical Sciences 2016) Back to browse issues page