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:: Volume 20, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2015) ::
SJKU 2015, 20(5): 93-101 Back to browse issues page
Association of 1082G/A estrogen receptor genes polymorphisms with recurrent abortions using AS-PCR
Sahar Daraei , Seyed Abdolhamid Angaji Dr, Saeed Morovvati 1, Mohammad Tahmaseb Dr, Neda Asari
1- , Morovvati@bmsu.ac.ir
Abstract:   (2916 Views)

Background and Aim: Abortion is spontaneous termination of pregnancy before the 20th week. Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses. There are several known risk factors associated with recurrent miscarriages, including genetic, endocrine, autoimmune, anatomical. Causes of recurrent miscarriages in 50% of the cases remain unexplained. It has been hypothesized that genetic polymorphism in estrogen receptor genes would be associated with recurrent miscarriages.

Material and Materials: This study included 80 patients with a history of three or more consecutive unexplained abortions and 80 women with at least 2 live births without any miscarriage. Then we investigated estrogen receptor gene polymorphism in the participants by allele specific polymerase chain reaction (AS-PCR) method.

Results: The frequencies of rs1256149 polymorphisms among the women with recurrent abortions and also the women in the control group were 80% and 62.5 % respectively. There was a significant difference in the genotype frequencies between RPL and the control groups (p=0.028).

Conclusion: These findings indicated that estrogen receptor polymorphism can be regarded as a genetic marker for recurrent spontaneous abortions.

Keyword: Estrogen receptor gene, Polymorphisms of 1082G/A, Recurrent

Background and Aim: Abortion is spontaneous termination of pregnancy before the 20th week. Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses. There are several known risk factors associated with recurrent miscarriages, including genetic, endocrine, autoimmune, anatomical. Causes of recurrent miscarriages in 50% of the cases remain unexplained. It has been hypothesized that genetic polymorphism in estrogen receptor genes would be associated with recurrent miscarriages.

Material and Materials: This study included 80 patients with a history of three or more consecutive unexplained abortions and 80 women with at least 2 live births without any miscarriage. Then we investigated estrogen receptor gene polymorphism in the participants by allele specific polymerase chain reaction (AS-PCR) method.

Results: The frequencies of rs1256149 polymorphisms among the women with recurrent abortions and also the women in the control group were 80% and 62.5 % respectively. There was a significant difference in the genotype frequencies between RPL and the control groups (p=0.028).

Conclusion: These findings indicated that estrogen receptor polymorphism can be regarded as a genetic marker for recurrent spontaneous abortions.

Keyword: Estrogen receptor gene, Polymorphisms of 1082G/A, Recurrent pregnancy loss.

 

Received: Jan 13, 2015      Accepted: May 31, 2015pregnancy loss.

Received: Jan 13, 2015      Accepted: May 31, 2015

Keywords: Estrogen receptor gene, Polymorphisms of 1082G/A, Recurrent pregnancy loss.
Full-Text [PDF 269 kb]   (1361 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/11/27 | Accepted: 2015/11/27 | Published: 2015/11/27
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Daraei S, Angaji S A, Morovvati S, Tahmaseb M, Asari N. Association of 1082G/A estrogen receptor genes polymorphisms with recurrent abortions using AS-PCR. SJKU. 2015; 20 (5) :93-101
URL: http://sjku.muk.ac.ir/article-1-2043-en.html


Volume 20, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2015) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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