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:: Volume 20, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2015) ::
SJKU 2015, 20(3): 113-139 Back to browse issues page
Mesenchymal Stem Cell Transplantation: Immunobiology, Therapeutic Applications and Challenges- A Review Article
Mohammad Reza Nikbakht Dr, Mahin Nikougoftar Zarif Dr, Farhad Oubari 1, Kamran Mansouri Dr, Roghieh Hosseini Kia , Mahboobeh Hosseini Kia , Ahmad Tajeh Miri
1- , Foubari@mbrc.ac.ir
Abstract:   (4265 Views)
Background and Aim: Mesenchymal stem cells are adult, non-hematopoietic, mulipotent and self-renewal cells. These cells were first isolated from bone marrow and considered as the most important cells in cell therapy. These cells have been used in clinical trials (animal models) about more than a decade. Regarding immunomodulatory properties through immunosuppressive factors and their repair potency, these cells have been widely used in the treatment of immunological (chronic and autoimmune diseases) and non-immunological diseases (tissue engineering, tissue repair, degenerative and malignant diseases.( This review aimed to study the therapeutic roles, immunobiology and challenges ahead of mesenchymal stem cells. Material and Methods: At first articles related to mesenchymal stem cells were searched from valid databases such as Wily Online Library, ISI web of science, Springer Link, Sciencedirect, Pubmed, google scholar, SID, and ISC. Then, the related articles studied from 2002 to 2014 were searched. They were about the modulatory role, therapeutic effects (in immunologic and non-immunologic diseases) and clinical applications of mesenchymal stem cells. Results: The obtained results showed a high potential of mesenchymal stem cells, isolated from different sources in clinical trials (preclinical and clinical). Mesenchymal stem cells have a key role in immunomodulation through secreted factors and cell-cell contact in inflammatory diseases, as well as tissue restoration by homing via adhesion molecules and chemokines in cells that has been destructed due to physiologic or pathologic causes (non-inflammatory and destructive diseases). In addition, it has anticancer features for nanoparticle delivery to tumors and consequently angiogenesis prevention. Despite mentioned points, use of mesenchymal stem cells has some risks such as tumor induction, infection transmission, and ectopic tissue formation in receiving individual. Conclusion: The therapeutic role of mesenchymal stem cells in destructive and autoimmune diseases has been proved. Given challenges in using mesenchymal stem cells in cell therapy and the standards (according to protocols), these cells can be used widely in the future. Keywords: Mesenchymal stem cell transplantation, Immunomodulation, Cell therapy, Regenerative medicine, Tissue engineering, Cell-cell contact, Soluble factor Received: Dec 7, 2014 Accepted: Mar 3, 2015
Keywords: Mesenchymal stem cell transplantation, Immunomodulation, Cell therapy, Regenerative medicine, Tissue engineering, Cell-cell contact, Soluble factor
Full-Text [PDF 4304 kb]   (1653 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/07/13 | Accepted: 2015/07/13 | Published: 2015/07/13
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Volume 20, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2015) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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