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:: Volume 19, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2014) ::
SJKU 2014, 19(4): 109-117 Back to browse issues page
Association of intron 3 16 bp duplication polymorphism of p53 with thyroid cancer in northwest of Iran
Mohammad Ali Hossein Pour Feizi Dr * 1, Roghiyeh Dehghan Alvar 2, Naser Pouladi Dr3, Esmail Babaie Dr4, Vahid Montazeri Dr5, Ashraf Fakhrjoo Dr6, Rayhaneh Ravanbakhsh Gavgani 2, Parvin Azarfam 2
1- Professor Tabriz University , pourfeiz@eastp.ir
2- Tabriz University
3- Assistant Professor Azarbaijan Shahid Madani University
4- Assistant Professor Tabriz University
5- Noor-E-Nejat Hospital, Tabriz
6- Professor Tabriz University of Medical Science
Abstract:   (2522 Views)
Background and Aim: Intron 3 16 bp duplication polymorphism of p53 gene has been associated with increased risk of colorectal, breast and lung cancers. Nevertheless there are inconsistent results and we need more studies to understand the importance of this polymorphism in increased risk of cancer predisposition. The aim of this study was to assess the association of 16 bp duplication polymorphism of p53 with thyroid cancer risk. Material and Methods: This case-control study included 105 thyroid patients and 170 controls. Cases and controls were matched for age, sex and ethnicity. Genomic DNA was extracted from peripheral blood samples and tumor tissues. P53 PIN3 genotype was determined using PCR products length analysis on polyacrylamide gel. Result: In the control and case groups, 62.9% and 53.3% had no 16 bp insertion, 7.1% and 8.6% had insertion in both p53 alleles and 30% and 38.1% were heterozygous, respectively. There were no significant differences between the case and control groups in regard to genotype frequencies as well as allelic frequencies. Conclusion: According to the results of our study PIN3 16 bp duplication polymorphism of p53 could not be considered as a risk factor for predisposition to thyroid cancer in northwest of Iran. Key words: Intron 3, P53 gene, Polymorphism, Thyroid Cancer. Received: Dec 14, 2013 Accepted: Sep 20, 2014
Keywords: Intron 3, P53 gene, Polymorphism, Thyroid Cancer.
Full-Text [PDF 221 kb]   (687 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/12/18 | Accepted: 2014/12/18 | Published: 2014/12/18
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Volume 19, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2014) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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