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:: Volume 11, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2006) ::
SJKU 2006, 11(2): 68-77 Back to browse issues page
Zinc status in β-thalassemic adolescents and its association with low bone mass density
Seyed Mahmood Tabatabaie Dr 1, Mir Reza Bekheirnia Dr, Alireza Abdollah Shamshirsaz Dr, Bagher Larijani Dr2, Masoud Kimiagar Dr2, Seyed Morteza Tabatabaiefar Dr
1- Professor , emrc@tums.ac.ir
2- Professor
Abstract:   (10824 Views)
Background and Aim: Trace elements have been considered to play critical roles in bone metabolism. The aim of this study was to determine serum zinc profile and its association with bone mineral density (BMD) abnormalities in thalassemic patients. Materials and Methods: Serum zinc levels of 131 transfusion-dependent β-thalassemic patients, between 10-20 years of age, were measured by flame-atomic absorption spectrophotometry (F-AAS). BMD values at lumbar (L1-L4) and femoral neck were determined by dual x-ray absorptiometry (DXA). Daily dietary zinc and calcium intake were evaluated by food frequency questionnaires. Patients’ history of treatment and demographic data were obtained. Results: Low serum zinc was present in 84.8% of the patients and severely low levels detected in 44.7%. In 68.7% and 17.6% of the patients BMD z-scores less than (-2) were observed at lumbar and femoral regions. Female patients with severe zinc deficiency had lower lumbar BMD z-scores (-3.26) in comparison to other females (-2.54). Serum zinc levels of female patients with femoral BMD z-scores less than (-2), were significantly lower than those of other females. Conclusion: Considering low serum zinc level and decreased daily zinc intake, proper nutrition of thalassemic patients showld be regarded important
Keywords: serum zinc, thalassemia, bone mineral density, osteoporosis, dietary zinc intake
Full-Text [PDF 172 kb]   (1121 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/05/13
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Volume 11, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2006) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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