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:: Volume 19, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2014) ::
SJKU 2014, 19(2): 31-39 Back to browse issues page
Prevalence of non-tuberculosis mycobacteria in patients referring to Mycobacteriology Research Center of Iran
Zahra Derakhshani Nezhad 1, Parisa Farnia Dr2, Fatemeh Maryam Sheikholslami 2, Mona Afraei Karahrudie 2, Mohadeseh Mozafari 2, Shima Seif 2, Kimia Taghavi 2, Rashid Ramazanzadeh Dr3, Mohammad Reza Masjedi Dr2, Ali Akbar Velayati Dr2
1- Shahid Beheshti University of Medical Sciences , sh_derakhshani@yahoo.com
2- Shahid Beheshti University of Medical Sciences
3- Kurdistan University of Medical Sciences
Abstract:   (6040 Views)
Background and Aim: Considering the increasing significance of diseases due to NTM all over the world, we investigated the burden of such diseases in our region. The aim of this study was to assess NTM prevalence from different clinical samples during a period of 8 years in Massih Daneshvari Hospital, in Iran. Material and method: This descriptive study was performed on 8322 samples obtained from pulmonary TB patients in Mycobacteriology Research Center from 2004 -2012. Using Tb1 and Tb2 primers, a 190 bp fragment of IS6110 gene was amplified in order to identify Mycobacterium species. Specimens with negative IS6110 PCR results were analyzed with PCR-RFLP using hsp65 gene, for NTM investigation. Results: Out of 8322 samples, we identified 124 (1.5%) strains of NTM. The mean age of the patients was 57 ± 18/9 years (age range: 7 - 88 years). 55/6 % of the patients were male. The most common species detected in our study were Mycobacterium simiae (44.3%), Mycobacterium chelonae (16.9%) and Mycobacterium kansasii (12.9%). Conclusion: We found a high prevalence rate of Mycobacterium simiae among our patients. Treatment protocols for NTM are different from the protocols for Mycobacterium tuberculosis complex, so early diagnosis of these species will be of great importance. Key words: NTM, Non tuberculous mycobacteria, hsp65 Received: Jan 22, 2013 Accepted: Feb 2, 2014
Keywords: NTM, Non tuberculous mycobacteria, hsp65
Full-Text [PDF 291 kb]   (1398 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/06/1 | Accepted: 2014/06/1 | Published: 2014/06/1
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Derakhshani Nezhad Z, Farnia P, Sheikholslami F M, Afraei Karahrudie M, Mozafari M, Seif S, et al . Prevalence of non-tuberculosis mycobacteria in patients referring to Mycobacteriology Research Center of Iran. SJKU. 2014; 19 (2) :31-39
URL: http://sjku.muk.ac.ir/article-1-1365-en.html


Volume 19, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2014) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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