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:: Volume 19, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2014) ::
SJKU 2014, 19(2): 9-20 Back to browse issues page
Comparison between the effects of ethanolic extract of Artemisia annua and chloroquine on Plasmodium berghei in white mice
Zaynab Karbalaei pazoki 1, Mehdi Nateghpour Dr2, Amir Hossein Maghsood Dr 3, Efat Souri Dr2, Afsaneh Motevalli Haghi 4, Leila Farivar 4, Masoumeh Khodadadi 4
1- Hamadan University of Medical Sciences
2- Professor Tehran University of Medical Sciences
3- Assistant Professor Hamadan University of Medical Sciences , a.h.maghsood@umsha.ac.ir
4- Tehran University of Medical Sciences
Abstract:   (7551 Views)
Background and Aim: Considering the importance of using native and traditional herbal medicines in the treatment of malaria, we made a comparison between the effects of an ethanolic extract of Artemisia annua and chloroquine on Plasmodium berghei in Sourian mice. Material and Method: In this study 50 Sourian mice were divided into 10 groups, each group consisted of five mice. The evaluation was done according to the Peters test. Nine of ten groups were infected with P. berghei. The first 6 groups were given extracts of Artemisia annua at different concentrations. The seventh and eighth groups received chloroquine and placebo, respectively. The ninth group received no treatment (control group).The tenth group was not infected with Plasmodium berghei and did not receive any treatment and was used for determination of accidental mortality of the mice. In each group, the levels of parasitaemia were determined on the 4th & 7th days, and compared with those of the control group. To find the most effective concentration, the test was repeated with 55 mice divided into 11 groups using limited spectrum of drug concentrations. We used SPSS software and T-test for data analysis. Results: The results indicated that Artemisia annua extract at the concentrations of 1100 and 1300 mg/kg significantly decreased P. berghei parasitaemia in the infected mice, but at the concentration of 1100 mg/kg Artemisia annua had less toxicity(P<0.05). Conclusion: According to the results of this study Artemisia annua at the concentration of 1100 mg/kg showed considerable effect on P. berghei. Keywords: Plasmodium berghei, Artemisia annua, Treatment, Chloroquine, Sourian mice. Received: Feb 21, 2013 Accepted: Feb 16, 2014
Keywords: Plasmodium berghei, Artemisia annua, Treatment, Chloroquine, Sourian mice.
Full-Text [PDF 424 kb]   (1179 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/06/1 | Accepted: 2014/06/1 | Published: 2014/06/1
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Volume 19, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2014) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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