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:: Volume 18, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2013) ::
SJKU 2013, 18(3): 55-63 Back to browse issues page
The effect of donepezil on morphine-induced withdrawal syndrome in rats
Esmael Izadpanah Dr1, Ali Abdolmaleki 2, Saro Khatibi Baneh 3, Majid Ghaderi 4, Soleiman Kurd 5, Kambiz Hasanzadeh Dr 6
1- Assistant Professor Kurdistan University of Medical Sciences
2- Islamic Azad University of Hamedan
3- Payame Noor University, Tehran
4- Razi University, Kermanshah
5- Kurdistan University
6- Assistant Professor Kurdistan University of Medical Sciences , kambizhassanzadeh@gmail.com
Abstract:   (8217 Views)
ABSTRACT Background and Aim: Long-term exposure to opiates induces physical and psychological dependency. Despite a large number of studies on this subject, cellular mechanism involved in this phenomenon is not yet exactly clear. In this study, we investigated the effects of donepezil, an acetylcholine esterase inhibitor, on morphin-induced withdrawal symptoms in rats. Material and Method: In this experimental study,6 groups of male Sprague Dawly rats weighting between 225 and 300 g, received 10 mg/kg , ip morphine/ day in addition to 1 ml/kg,ip saline or 0.5, 1 and 1.5 mg/kg, ip donepezil. In order to induce dependency, morphine was administered subcutaneously every 12 hours for nine days. On the ninth day,30 minutes after the last dose of morphine, control groups received 1 ml/kg, ip saline and experimental groups received ip donepezil. After 30 min, naloxone (4 mg/kg, ip) were administered for all groups and the withdrawal symptoms including: jumping, rearing, genital grooming, abdomen writhing, body grooming and wet dog shake, were recorded for 60 minutes. Results Our results showed that donepezil decreased withdrawal symptoms, also it could attenuate the total withdrawal score, significantly. Conclusion: The results of this study showed that donepezil as an acetylcholine esterase inhibitor, could decrease withdrawal symptoms in rats. Key words: Donepezil, Morphine, Dependency, Withdrawal symptoms Received: Jun 15, 2012 Accepted: Oct 10, 2012 Conflict of interest: None declared
Keywords: Donepezil, Morphine, Dependency, Withdrawal symptoms
Full-Text [PDF 241 kb]   (900 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/10/4 | Accepted: 2013/10/9 | Published: 2013/10/9
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Volume 18, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2013) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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