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:: Volume 12, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2007) ::
SJKU 2007, 12(1): 46-53 Back to browse issues page
The effect of a 6 month treatment course of male healthy rats by chlorpropamide and glibenclamide on vascular tone of aorta
Esmael Izadpanah * 1, Ghader Saleh Nezhad , Salahedin Ahmadi Dr2, Siroos Shahsavari
1- , eizadpanah2000@yahoo.com
2- Assistant Professor
Abstract:   (11064 Views)
Background and Aim: Diabetes mellitus is the most common endocrine disorder with an ever-increasing prevalence. Cardiovascular complications are the major cause of death in diabetic patients. Type II diabetes mellitus is usually treated by sulfonyureas. There are controversial reports regarding cardiovascular side effects of these drugs. Conflicting evidences exist about side effects of the first and second-generation sulfonylureas. In this study, the vascular effects of chlorpropamide and glibenclamide (first and second generations of sulfonylureas respectively) were investigated in healthy male rats. Materials and Methods: Male rats were treated by the above–mentioned drugs for six months and the response of aortic rings to acetylcholine, isosorbide dinitrate and phenylephrine were studied and compared to normal control group. Data were analyzed by means of ANOVA test. Results: There was no significant difference between the response of aortic rings of treated and control group to acetylcholine, isosorbide dinitrate and phenylepherine. Conclusion: Sulfonylureas through closing ATP dependent potassium channels, which exist in beta-cells of pancreas and other organs such as heart and vascular smooth muscles may affect the vascular tone. Based on the results of this study long term oral consumption of chlorpropamide and glibenclamide in normal rats did not affect aortic contractile property. Further studies are needed to clarify the vascular effects of sulfonylureas.
Keywords: Chlorpropamide, Glibenclamide, Vascular effects, Aorta, Rat
Full-Text [PDF 183 kb]   (1090 Downloads)    
Type of Study: Research | Subject: General
Received: 2009/05/5
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Volume 12, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2007) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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