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:: Volume 18, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2013) ::
SJKU 2013, 18(1): 85-93 Back to browse issues page
Comparison of the side effects of blood transfusion between pre-storage filtration and post-storage filtration methods in thalassemia patients.
Mohammad Abbasi Dr1, Tahereh Abbasi Dr * 2, Mohammad Taghi Ghodarzi Dr1, Afshin Mohammadi Dr3
1- Hamadan University of Medical Sciences
2- Hamadan University of Medical Sciences , taherehabbasi998@yahoo.com
3- Research Center of Iranian Blood Transfusion Organization, Hamadan Blood Center
Abstract:   (6685 Views)
Background and Aim: Application of WBC-reduced blood products can decrease side effects related to white blood cells transfer, such as febrile reactions, CMV infection and …. Advances in biotechnology have led to production and development of filters that are capable of reducing WBC hence, diminishing these side effects. The aim of this study was to determine and compare side effects of blood transfusion between pre-storage filtration and post-storage filtration methods in thalassemia patients. Material and Methods: This study was a randomized clinical trial with crossover design and included adult thalassemia patients referring to hospital from 1388 to 1389 and receiving alternately red blood cell concentrates by using pre-storage and post-storage filtration methods. Side effects of blood transfusion including hypotension, fever, hemoglobin drop and blood transfusion rate were recorded and compared between the two methods. Data were introduced in to SPSS software and analyzed by paired t-test, χ2, t-test and P>0.05 was considered significant. Results: Comparison of the incidences of hypotension, FNHTR, allergic reactions and hemoglobin drop between pre-storage and post-storage filtration methods showed no significant differences. A significant difference was observed in the transfusion rates between the two methods which indicated a lower transfusion rate in the pre-storage method (p<0.001). Conclusion: Pre-storage filtration method is not superior to post-storage filtration method for blood transfusion in thalassemia patients.
Keywords: Pre-storage filtration, Post-storage filtration, Leuko-reduction, Leukocyte filter, Febrile non-hemolytic transfusion reaction.
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Type of Study: Research | Subject: General
Received: 2013/04/27
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Abbasi M, Abbasi T, Ghodarzi M T, Mohammadi A. Comparison of the side effects of blood transfusion between pre-storage filtration and post-storage filtration methods in thalassemia patients.. SJKU. 2013; 18 (1) :85-93
URL: http://sjku.muk.ac.ir/article-1-1011-en.html


Volume 18, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2013) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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