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Comparison of the side effects of blood transfusion between pre-storage filtration and post-storage filtration methods in thalassemia patients.
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Mohammad Abbasi1   , Tahereh Abbasi 2, Mohammad Taghi Ghodarzi1 , Afshin Mohammadi3 |
1- Hamadan University of Medical Sciences
2- Hamadan University of Medical Sciences , taherehabbasi998@yahoo.com
3- Research Center of Iranian Blood Transfusion Organization, Hamadan Blood Center |
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Abstract: (10135 Views) |
| Background and Aim: Application of WBC-reduced blood products can decrease side effects related to white blood cells transfer, such as febrile reactions, CMV infection and ….
Advances in biotechnology have led to production and development of filters that are capable of reducing WBC hence, diminishing these side effects. The aim of this study was to determine and compare side effects of blood transfusion between pre-storage filtration and post-storage filtration methods in thalassemia patients.
Material and Methods: This study was a randomized clinical trial with crossover design and included adult thalassemia patients referring to hospital from 1388 to 1389 and receiving alternately red blood cell concentrates by using pre-storage and post-storage filtration methods. Side effects of blood transfusion including hypotension, fever, hemoglobin drop and blood transfusion rate were recorded and compared between the two methods. Data were introduced in to SPSS software and analyzed by paired t-test, χ2, t-test and P>0.05 was considered significant.
Results: Comparison of the incidences of hypotension, FNHTR, allergic reactions and hemoglobin drop between pre-storage and post-storage filtration methods showed no significant differences. A significant difference was observed in the transfusion rates between the two methods which indicated a lower transfusion rate in the pre-storage method (p<0.001).
Conclusion: Pre-storage filtration method is not superior to post-storage filtration method for blood transfusion in thalassemia patients. |
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| Keywords: Pre-storage filtration, Post-storage filtration, Leuko-reduction, Leukocyte filter, Febrile non-hemolytic transfusion reaction. |
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Full-Text [PDF 243 kb]
(6506 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2013/04/27 | Published: 2013/05/15
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