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:: Volume 25, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2021) ::
SJKU 2021, 25(6): 1-9 Back to browse issues page
Protective Effect of Human Menopausal Gonadotropins on Rat Ovarian Structure Following Use of Nandrolone Decanoate: From a Histological Standpoint
Hossein Bordbar1 , Afsoon Bordbar2 , Farzaneh Golfeshan Dr3 , Ebrahim Rahmani moghadam 4
1- Histomorphometry and Stereology Research Center, Department of Anatomical Sciences, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Department of Orthodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Anatomical Sciences, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran. , ebrahimrahmani1374@gmail.com
Abstract:   (315 Views)
Background and Aim: Nandrolone decanoate is known as one of the most destructive environmental factors in the reproductive system in men and women. In this study, we assessed the protective effect of gonadotropins (hMG) on histological changes of rat ovarian structure.
Materials and Methods: 50 female rats were divided into 5 groups, including control, nandrolone decanoate (ND), hMG, ND + hMG, and sham group (0.1 ml of olive oil and 0.1 ml sodium chloride 0.09%). After 4 weeks, qualitative histological studies were performed, and the total volume of ovarian vessels was estimated by stereological methods.
Results: Nandrolone decanoate increased the mean volume of vessels (66%) and the use of hMG + ND led to an increased mean volume of vessels (83%) compared to the use of 0.1 ml of olive oil and 0.1 ml sodium chloride 0.09% (sham group) (P<0.001). Histological studies showed induction of ovarian cysts in ND treated group and the administration of hMG + ND decreased follicular damage.
Conclusion: Nandrolone decanoate increased the total volume of ovarian vessels and induced histological changes in ovarian tissue. the Use of hMG with ND increased the total volume of ovarian vessels and prevented the harmful effects of ND on ovarian follicles.
Keywords: Human menopausal gonadotropins, Ovary, Nandrolone decanoate, Rat
Full-Text [PDF 524 kb]   (228 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/05/23 | Accepted: 2020/07/15 | Published: 2021/01/29
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bordbar H, bordbar A, golfeshan F, rahmani moghadam E. Protective Effect of Human Menopausal Gonadotropins on Rat Ovarian Structure Following Use of Nandrolone Decanoate: From a Histological Standpoint. SJKU. 2021; 25 (6) :1-9
URL: http://sjku.muk.ac.ir/article-1-5052-en.html


Volume 25, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2021) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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