Scientific Journal of Kurdistan University of Medical Sciences
مجله علمي دانشگاه علوم پزشكي كردستان
SJKU
General
http://sjku.muk.ac.ir
54
journal54
1560-652X
2345-4040
sjku
10.61186/sjku
en
jalali
1404
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1
gregorian
2025
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اثر غلظت اکسیژن سلولی بر اثربخشی زیستشناختی نسبی پرتوهای ایکسکمانرژی
The Effect of Cell Oxygen Concentration on the Relative Biological Effectiveness of Low Energy X-rays
فیزیک پزشکی
Medical Physics
پژوهشي اصیل
Original Research
<p><span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">زمینه و هدف:</span></span></b> <span b="" lang="FA" style="font-family:" zar=""><span style="color:black">درمان سرطان با استفاده از پرتوهای یونیزان روشی مؤثر برای مدیریت و کنترل سرطان</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های مختلف است. ازآنجاکه حضور اکسیژن درون سلول موجب ایجاد آسیب</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های مختلف به مولکول </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">DNA</span></span> <span b="" lang="FA" style="font-family:" zar=""><span style="color:black">می</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">شود، هدف از انجام مطالعه حاضر محاسبه میزان اثرات زیست</span></span><span dir="LTR" style="color:black">­</span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">شناختی نسبی(</span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RBE</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">)</span></span> <span b="" lang="FA" style="font-family:" zar=""><span style="color:black">پرتوهای ایکس</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">کم انرژی مورد</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">استفاده در پرتودرمانی حین عمل در غلظت</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های مختلف اکسیژن درون سلول، با استفاده از رویکرد شبیه</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">سازی مونت­کارلو است.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">مواد و روش­ها:</span></span></b> <span b="" lang="FA" style="font-family:" zar=""><span style="color:black">جهت برآورد میزان </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RBE</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> در این مطالعه ابتدا طیف الکترون</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های ثانوی ایجادشده در فاصله یک سانتی</span></span><span cambria="" lang="FA" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">متری از پروب لخت دستگاه درمانی </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">INTRABEAM</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> با استفاده از یک مدل مونت</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">کارلوی اعتبارسنجی</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">شده توسط ابزار مونت</span></span><span cambria="" lang="FA" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">کارلوی </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">Geant4</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> محاسبه شد. پس از محاسبه طیف الکترون</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های ثانوی، مقادیر </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RBE</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> پرتوهای ایکس کم</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">انرژی حاصل از دستگاه درمانی مذکور در غلظت</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های مختلف اکسیژن درون سلول، توسط کد میکرودوزیمتری </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">MCDS</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> محاسبه شد.</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">یافتهها:</span></span></b> <span b="" lang="FA" style="font-family:" zar=""><span style="color:black">نتایج حاصل از این بررسی نشان داد که میزان </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RBE</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> با افزایش غلظت اکسیژن درون سلول افزایش می</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">یابد به طوری که با افزایش غلظت اکسیژن از صفر تا صد درصد، مقادیر </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RBE</span></span><sub><span dir="LTR" style="color:black">SSB</span></sub><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> و </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RBE</span></span><sub><span dir="LTR" style="color:black">DSB</span></sub><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> به ترتیب حدود 1/6 و 2/3 برابر افزایش یافتند. علاوه بر این در بیشتر غلظت</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های اکسیژن مورد</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">بررسی مقادیر </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RBE</span></span><sub><span dir="LTR" style="color:black">DSB</span></sub><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"> بزرگتر از یک بوده که ­نشان­دهنده میزان بالای اثرات زیست</span></span><span cambria="" lang="FA" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">شناختی نسبی پرتوهای ایکس کم</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">انرژی موردمطالعه در مقایسه با فوتون</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های پرانرژی است.</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">نتیجهگیری: </span></span></b><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">با توجه به نتایج بهدستآمده می</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">توان چنین استنباط نمود که میزان غلظت اکسیژن درون سلول از جمله عوامل مؤثر در ایجاد اثرات زیست</span></span><span cambria="" lang="FA" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">شناختی ناشی از پرتوهای ایکس حاصل از دستگاه درمانی </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">INTRABEAM</span></span><span b="" style="font-family:" zar=""><span style="color:black"> است به طوری که در غلظت­های پایین اکسیژن، حساسیت سلول</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">ها نسبت به تابش</span></span><span cambria="" dir="LTR" style="font-family:"><span style="color:black">­</span></span><span b="" lang="FA" style="font-family:" zar=""><span style="color:black">های یونیزان کاهش می­یابد.</span></span></span></span></span></span></span></span></span><br>
</p>
<span style="font-size:12pt"><span style="background:white"><span style="line-height:normal"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Background and Aim:</span></b><span style="color:black"> Cancer treatment using ionizing radiation is an effective modality for the management and control of various cancers. The presence of oxygen inside the cell causes various damages to the DNA molecule. The purpose of this study is to calculate the relative biological effectiveness (RBE) of low-energy X-rays during cancer treatment using intraoperative radiotherapy at different oxygen concentrations within the cell through a Monte Carlo (MC) simulation approach.</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="background:white"><span style="line-height:normal"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Materials and Methods:<i> </i></span></b><span style="color:black">To estimate the RBE values in this study, the secondary electron spectrum, which was emitted from 1 cm after the bare probe surface, was calculated with the Geant4-validated MC model of the INTRABEAM system. After the calculation of the secondary electron energy spectrum, the RBE values of the emitted low-energy X-rays from the INTRABEAM system at different cell oxygen concentrations were calculated by the MCDS MC code.</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="background:white"><span style="line-height:normal"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Results:<i> </i></span></b><span style="color:black">The results showed that the RBE values increase with the oxygen concentration increment in the cell. When the oxygen concentration increments from 0 to 100%, the RBE<sub>SSB</sub> and RBE<sub>DSB</sub> values increase by about 1.6 and 2.3 times, respectively. Furthermore, in most of the studied oxygen concentrations, the RBE<sub>DSB</sub> values were greater than unity, which indicates the high relative biological effectiveness of the considered low-energy X-rays compared to high-energy photons.</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="background:white"><span style="line-height:normal"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="color:black">Conclusion: </span></b><span style="color:black">Accordingly, it can be concluded that cell oxygen level is one of the influential factors for RBE assessments relevant to the emitted X-rays from the INTRABEAM system, where the cell sensitivity to the ionizing radiation decreases at low-oxygen levels.</span></span></span></span></span></span><br>
غلظت اکسیژن, اثرات زیستشناختی نسبی, دستگاه INTRABEAM, پرتوهای ایکس کمانرژی, شبیهسازی مونتکارلو.
Oxygen concentration, Relative biological effectiveness, Low energy X-rays, INTRABEAM system, Monte Carlo simulation
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http://sjku.muk.ac.ir/browse.php?a_code=A-10-7381-1&slc_lang=fa&sid=1
Reza
Shamsabadi
رضا
شمس ابادی
rshams220@gmail.com
5400319475328460070046
5400319475328460070046
No
Ph.D., Physics department Hakim Sabzevari University, Sabzevar, Iran
دانشگاه حکیم سبزواری
Hamid Reza
Baghani
حمیدرضا
باغانی
hamidreza.baghani@gmail.com
5400319475328460070047
5400319475328460070047
Yes
Associated professor, Physics department Hakim Sabzevari University, Sabzevar, Iran
دانشگاه حکیم سبزواری