fa بررسی کارآمدی بیوپسی سوزنی گره لنفاوی در تشخیص بیماران با لنفادنوپاتی پزشکی- پاتولوژی Medicine - Pathology پژوهشي اصیل Original Research <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">زمینه و هدف:</span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">بیوپسی سوزنی</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">یک روش کم تهاجمی است و اثرات جانبی کمتری در مقایسه با روش‌های جراحی </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">دارد و</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">اطلاعات</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">صحیحی در مورد ماهیت تومور می‌دهد. </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">هدف از این تحقیق، بررسی کارآمدی </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">بیوپسی سوزنی </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">در تشخیص بیماران با لنفادنوپاتی است.</span></span><b> </b><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Zar""></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:93.9pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">مواد و روش &shy;ها</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">: </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">از سال 1393 تا 1397 </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">تعداد 153</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> بیمار با لنفادنوپاتی، تحت </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">بیوپسی سوزنی قرار گرفتند.</span></span><b> </b><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">تکنیک ایمونوهیستوشیمی- رنگ‌آمیزی با مارکر های متناسب روی نمونه ‌ها اجرا شد. بیوپسی اکسیژنال، اطلاعات بالینی و اطلاعات رادیولوژی بررسی شد. جهت تجزیه و تحلیل از </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">آزمون کای</span></span>&nbsp;<span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">دو، آنالیز </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">واریانس یک‌ طرفه و آزمون تعقیبی توکی به‌وسیله نرم‌افزار 21-</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">SPSS</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> استفاده شد (0/05></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">). صحت</span></span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">بیوپسی سوزنی به‌وسیله ارزیابی تشخیصی با فاصله اطمینان 95% به دست آمد. </span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:93.9pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">یافته‌ها</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">: لنفوم سلول</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> B </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">بزرگ</span></span>&nbsp;<span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">و منتشر، فراوانی بیشتری داشت (41%). تشخیص هیستوپاتولوژیک حاصل از بیوپسی سوزنی، در 83/23% از بیماران صحیح بوده است. 11/11% با استفاده از بیوپسی اکسیژنال و 88/88% با یافته‌های بالینی و رادیولوژی تائید شدند. بین میانگین سنی و محل بروز لنفادنوپاتی (0/02=</span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">) و میان میانگین سنی و تشخیص پاتولوژی (0/001></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">)، ارتباط معنی‌داری وجود داشت. </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">صحت، حساسیت و ارزش اخباری مثبت </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">بیوپسی سوزنی به ترتیب؛</span></span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">90%، 100% و 90% بود.</span></span><span dir="LTR" style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">نتیجه‌گیری:</span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> تشخیص </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">بیوپسی سوزنی</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> در اکثر موارد صحیح بود و کارآمدی آن مشاهده شد. </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">نتایج حاصل حاضر بیوپسی سوزنی را به عنوان یک روش مناسب و بدون اثرات جانبی، جهت بررسی علت لنفادنوپاتی توصیه می‌کند.</span></span><span dir="LTR" style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background and Aim:</span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Core needle biopsy (CNB) is less invasive and has fewer side effects compared to surgical procedures, and provides accurate information about the nature of the tumor. The aim of this study was to evaluate the efficacy of CNB in the diagnosis of the cause of lymphadenopathy</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:93.9pt"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> In this study, 153 patients with lymphadenopathy underwent CNB from 2014 to 2018. Immunohistochemistry staining with appropriate markers was performed. Excisional biopsy, clinical and radiological data were evaluated using spss-21 softwere, data were analyzed by one way ANOVA and tukey test (p<0/05).</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:93.9pt"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Diffuse large B-cell lymphoma was more frequent (41%). Histopathological diagnosis of core needle biopsy was correct in 83.23% of the patients,among them 11.11% were confirmed by excisional biopsy and 88.88% by clinical and radiological findings. There was a significant relationship between the mean age of the patients and location of lymphadenopathy (P = 0.02) and also between the mean age and pathology diagnosis (P<0.001). The accuracy, sensitivity, and positive predictive value of CNB&nbsp;were 90%, 100%, and 90%, respectively.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Diagnosis of the cause of lymphadenopathy</span></span><b> </b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">by</span></span><b> </b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">CNB was correct in most cases and its diagnostic efficacy was confirmed. The present results recommend CNB as a suitable method without side effects for investigation of the cause of lymphadenopathy.</span></span></span></span></span><br> &nbsp; بیوپسی سوزنی, گره لنفاوی, لنفادنوپاتی Lymph node, Core needle biopsy, Lymphadenopathy 77 94 http://sjku.muk.ac.ir/browse.php?a_code=A-10-6575-1&slc_lang=fa&sid=1 Melika Oladzad ملیکا اولادزاد melikamehrad93@gmail.com 5400319475328460057930 5400319475328460057930 No Student Reseach Comitee, Babol University of Medical Sciences, Babol, Iran کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی بابل، بابل، ایران. Nasser Ghaemian ناصر قائمیان nghaemian41@yahoo.com 5400319475328460057931 5400319475328460057931 No Department of of Radiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی بابل، بابل، ایران Hemmatollah Gholinia Ahangar همت اله قلی نیا آهنگر h_gholinia@yahoo.com 5400319475328460057932 5400319475328460057932 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran مرکز تحقیقات عوامل اجتماعی مؤثر بر سلامت، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران Sahar Sadr Moharrerpour سحر صدرمحررپور drsaharsadr@gmail.com 5400319475328460057933 5400319475328460057933 No Assistant Professor of Pediatric Nephrology, Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran مرکز تحقیقات بیماری‌های غیر واگیر کودکان، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران. Housein Ghorbani حسین قربانی ghorbani7958@yahoo.com 5400319475328460057934 5400319475328460057934 Yes Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran مرکز تحقیقات سرطان، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران.