fa تاثیر فرکانس فضایی بر پارامترهای پتانسیل برانگیخته بینایی در ارزیابی تیزبینی پزشکی- چشم پزشکی Medicine - Ophthalmology پژوهشي اصیل Original Research <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">زمینه و هدف:</span></span></b></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> اندازه گیری تیزبینی با استفاده از </span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">VEP</span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">&nbsp; در بیمارانی که سطح همکاری پایینی دارند از اهمیت زیادی برخوردار است. لذا هدف از این مطالعه </span></span></span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="background:#fcfcfc"><span b="" style="font-family:" zar="">بررسی اثر فرکانس فضایی بر پارامترهای موج </span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="background:#fcfcfc"><span new="" roman="" style="font-family:" times="">VEP</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="background:#fcfcfc"><span b="" style="font-family:" zar=""> در ارزیابی </span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">تیزبینی با </span></span></span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="background:#fcfcfc"><span new="" roman="" style="font-family:" times="">Sweep VEP</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="background:#fcfcfc"><span b="" style="font-family:" zar=""> است.</span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Zar""></span></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">مواد و روش ها:</span></span></b></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> در این مطالعه مقطعی تعداد 63 دانشجوی دانشگاه علوم پزشکی با میانگین سنی 3/93 </span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">&plusmn;</span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> 22/81 سال انتخاب شدند. پس از معاینه کامل چشمی و اصلاح عیوب انکساری، بهترین دید اصلاح شده به صورت سابجکتیو با تست </span></span></span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Freiburg Acuity contrast test</span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span b="" style="font-family:" zar=""> تعیین و ثبت گردید. سپس </span></span></span></span></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">VEP</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> با دستگاه الکتروفیزیولوژی رولند برای رنج محدودی از فرکانس های فضایی از 2 تا 37/5 سیکل بر درجه ثبت گردید. پارامترهای ثبت شده شامل زمان های تاخیر </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">N1</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">، </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">P1</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">، </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">N135</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> و دامنه موج بود.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">یافته ها:</span></span></b> <span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">آزمون آنالیز واریانس با اندازه گیری تکراری نشان داد که اثر فرکانس فضایی (سایز محرک) بر دامنه موج ، زمان تاخیر </span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">N1</span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> ، زمان تاخیز </span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">P</span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="LTR" style="font-size:12.0pt">1</span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">&nbsp; ، زمان تاخیر </span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">N135</span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">&nbsp; معنی دار بوده است (0/001></span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="LTR" style="font-size:12.0pt">P</span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">). </span></span></span></span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">آزمون تی زوجی تفاوت معنی داری را در تیزبینی سابجکتیو و تیزبینی استخراج شده با&nbsp; </span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">VEP</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> نشان داد(0/001</span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">></span></span><span dir="LTR" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span arial="" style="font-family:">)</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">.</span></span></span></span></span></span></span><br> &nbsp;<span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" style="font-family:" zar="">نتیجه گیری:</span></span></span></b></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" style="font-family:" zar=""> با توجه به ارتباط معنی دار دامنه موج </span></span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">VEP</span></span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" style="font-family:" zar=""> با فرکانس فضایی بدست آمده در این مطالعه، می توان از تکنیک </span></span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Sweep VEP</span></span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" style="font-family:" zar=""> به عنوان ابزار ابجکتیو و معتبر در تخمین تیزبینی بویژه در افرادی که سطح همکاری کمی دارند استفاده کرد.</span></span></span></span></span></span></span> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background and Aim:</span></span></b></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Objective measurement of visual acuity using VEP is high valued in patients with low levels of cooperation. Therefore, this study aimed to investigate the effect of spatial frequency on VEP components in visual acuity using Sweep VEP.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Material and Methods</span></span></b></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">: In this cross-sectional study 63 medical students with an age of 22.81 &plusmn; 3.93 were selected. After a completed eye examination, refractive error was determined, and best-corrected visual acuity as subjective was recorded </span></span></span></span></span></span><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">by the Freiburg Acuity contrast test</span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">. Sweep VEP using the Roland electrophysiology system was recorded for various spatial frequencies from 2 to 37.5 cycles per degree. VEP components were the latencies of N1, P1, N135, and the amplitude of VEP.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Repeated measures of the ANOVA test showed that the effect of spatial frequency on latencies and amplitude of VEP was significant (P<0.001). Paired T-test showed that there was a significant difference between subjective visual acuity and extrapolation of visual acuity with VEP (P<0.001)</span></span></span></span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span></span><br> <span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b></span></span></span></span> <span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">According to the significant relationship between VEP amplitude and spatial frequencies of the visual stimuli obtained in this study, the Sweep VEP technique can be used as a valid and objective tool in the determination of visual acuity, especially in patients with low levels of cooperation</span></span></span></span></span></span></span><span class="fontstyle01" nimbusromandot-regular="" style="font-family:"><span style="color:#242021"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">.</span></span></span></span></span></span></span><br> <span dir="RTL"></span> تیزبینی, پتانسیل برانگیخته بینایی, فرکانس فضایی, زمان تاخیر, دامنه Amplitude, Latency, Spatial frequency, Visual acuity, Visual evoked potentials. 80 88 http://sjku.muk.ac.ir/browse.php?a_code=A-10-308-2&slc_lang=fa&sid=1 Monireh Mahjoob منیره محجوب mahjoob_opt@yahoo.com 0942017064 5400319475328460052804 Yes Assistant Professor, Health Promotion Research Center/Department of Optometry, Zahedan University of Medical Sciences, Zahedan, Iran. استادیار، مرکز ارتقا سلامت دانشگاه علوم پزشکی زاهدان / گروه اپتومتری، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران Javad Heravian جواد هرویان heraviansj@mums.ac.ir 5400319475328460052805 5400319475328460052805 No Professor, Department of Optometry, Mashhad University of Medical Sciences, Mashhad, Iran استاد، گروه اپتومتری، دانشگاه علوم پزشکی مشهد، مشهد، ایران