[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal Citation Index

 

Citation Indices from GS

AllSince 2019
Citations89785395
h-index3725
i10-index235137

 

..
Central Library of Kurdistan University of Medical Sciences
AWT IMAGE
..
Vice-Chancellery for Research and Technology
AWT IMAGE
..
SCImago Journal & Country Rank
:: Volume 26, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2021) ::
SJKU 2021, 26(4): 1-16 Back to browse issues page
Effect of fenofibrate on brain infarction, brain swelling and edema in focal-transient cerebral ischemia in rat
Hadi Vahidi1 , Shima Shahyad2 , Ali Noroozzadeh1 , Mohammad Taghi Mohammadi 3
1- Department of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
2- Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
3- Department of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran , Mohammadi.mohammadt@yahoo.com
Abstract:   (1778 Views)
Background and Aim: Increasing evidence has demonstrated that activation of peroxisome proliferator-activated receptor alpha (PPARα), which belongs to the nuclear receptor family of ligand-activated transcription factors, after cerebral ischemia exhibit neuroprotective functions including anti-oxidative, anti-apoptotic and anti-inflammatory effects. The aim of this study was to evaluate the pretreatment effects of PPARα agonist, fenofibrate, on brain infarction, tissue swelling, and brain edema in an experimental model of ischemic stroke.
Materials and Methods: The study included three groups of rats (N=36); sham, control ischemic, and treated ischemic groups. Brain ischemia was induced by 90 min middle cerebral artery occlusion (MCAO) followed by 24 hours reperfusion. Rats received fenofibrate (200 mg/kg/day) by oral route for 4 days before induction of MCAO. Neurological deficit score (NDS), infarct volume (TTC staining method), tissue swelling, and brain edema were assessed 24 hours after termination of MCAO.
Results: MCAO induced neurological dysfunction (2.83±0.16), brain infarction (282±30 mm3), brain swelling (15.13±2.29 %), and edema (17.23±1.97%) in the control ischemic group. Administration of fenofibrate in the treated ischemic rats significantly reduced neurological dysfunction (2.14±0.14), brain infarction (92±28 mm3), brain swelling (4.35±1.42%), and edema (5.49±1.44) compared to the rats in the control ischemic group.
Conclusion: Our findings indicated that activation of PPARα by a specific agonist, fenofibrate, effectively decreased the cerebral ischemia-reperfusion injuries as well as brain swelling and edema in an experimental model of ischemic stroke.
Keywords: Ischemic stroke, Fenofibrate, PPARα, Brain infarction, Brain edema
Full-Text [PDF 330 kb]   (988 Downloads)    
Type of Study: Applicable | Subject: General
Received: 2018/12/18 | Accepted: 2021/02/7 | Published: 2021/09/28
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vahidi H, Shahyad S, Noroozzadeh A, Mohammadi M T. Effect of fenofibrate on brain infarction, brain swelling and edema in focal-transient cerebral ischemia in rat. SJKU 2021; 26 (4) :1-16
URL: http://sjku.muk.ac.ir/article-1-4619-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 26, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2021) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.08 seconds with 44 queries by YEKTAWEB 4645