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:: Volume 27, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2022) ::
SJKU 2022, 27(3): 12-22 Back to browse issues page
Evaluation of the Effect of Topical Pistachio Hull Hydroalcoholic Extract Ointment on Wound Healing in Rat: A Histologic and Planimetric Study
Masoumeh Pourjabali1 , Leila Zarei 2, Vahid Ezzati Sarai3
1- Assistant Professor, Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
2- Associate Professor, Department of Anatomical Sciences, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. , leilazarei652@yahoo.com
3- Medical Student, Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
Abstract:   (1593 Views)
Background and Aim: Pistachio nut and hull have anti-inflammatory, antimicrobial and antioxidant effects. The aim of this study was to investigate the effects of pistachio hull hydroalcoholic extract ointment on wound healing process.
Materials and methods: For wound planimetric assessment, 20 healthy rats were randomly divided into 5 groups of 4, including control group (open wound without any intervention and treatment), positive control group (open wound with basic ointment without extract), and the 3 other groups receiving 1%, 2% and 4% ointments respectively. On the 7th  and 14th days, biopsies from wound tissues were taken and after Mason Trichrome staining we evaluated collagen. H&E staining was done for histopathological assessments.
Results: The results showed that wound treatment with pistachio hull ointment in the experimental groups showed a significant increase (P<0.05) in the percentage of wound healing rate. Also, there was a significant difference in the thickness of skin and collagen diameter, and reduction of edema between experimental and control groups (P<0.05). Also we found significant decrease in inflammatory cell count on the 14th day in the groups treated with pistachio hull extract compared to those in the control group (P<0.05), which was indicative of accelerated wound healing in the experimental groups.
Conclusion: According to the results of this study, pistachio hull hydroalcoholic extract ointment potentially possesses healing effects on the wound created in the skin of the rat. 
 
Keywords: Ointments, Medicinal plants, Plant extracts, Staining
Full-Text [PDF 676 kb]   (395 Downloads)    
Type of Study: Original Research | Subject: Pharmacology
Received: 2021/05/3 | Accepted: 2021/11/28 | Published: 2022/09/11
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Pourjabali M, Zarei L, Ezzati Sarai V. Evaluation of the Effect of Topical Pistachio Hull Hydroalcoholic Extract Ointment on Wound Healing in Rat: A Histologic and Planimetric Study. SJKU 2022; 27 (3) :12-22
URL: http://sjku.muk.ac.ir/article-1-6726-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 27, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2022) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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