Scientific Journal of Kurdistan University of Medical Sciences
مجله علمي دانشگاه علوم پزشكي كردستان
SJKU
General
http://sjku.muk.ac.ir
54
journal54
1560-652X
2345-4040
sjku
10.22034
en
jalali
1404
10
1
gregorian
2026
1
1
30
6
online
1
fulltext
fa
بررسی ارتباط بین تداخلات دارویی، مدت زمان بستری در بیمارستان و تعداد داروهای مصرفی در بیمارستان شهدای عشایر، خرمآباد
Investigating the Association Between Drug Interactions, Length of Hospital Stay and Number of Medications in Shohada-ye Ashayer Hospital, Khorramabad
فارماکولوژی
Pharmacology
پژوهشي اصیل
Original Research
<div class="WordSection1"><span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">زمینه و هدف:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> تداخلات دارویی (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDIs</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">) می</span></span><span dir="LTR" lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">‎</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">تواند باعث کاهش کارایی درمان، بروز عوارض جدی و حتی مرگ در بیماران شود. در بخش مراقبتهای ویژه (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">ICU</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">)، به دلیل تجویز داروهای بیشتر، احتمال وقوع این تداخلات افزایش مییابد. بنابراین، هدف مطالعه حاضر بررسی فراوانی، شدت و عوامل خطر مرتبط با وقوع </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDIs</span><span style="font-size:12.0pt"><span b="" style="font-family:" zar=""> در بیماران بستری در </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">ICU</span><span style="font-size:12.0pt"><span b="" style="font-family:" zar=""> می‏باشد و نتایج آن میتواند به بهبود مدیریت درمانی و کاهش عوارض ناشی از </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDIs</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> کمک کند</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">.</span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Zar""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">مواد و روش­ها</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">این مطالعه مقطعی بر روی 79 بیمار بستری در </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">ICU</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">های بیمارستان شهدای عشایر در شهر خرمآباد از ابتدای فروردین تا انتهای خرداد ماه سال 1400 انجام شد. جهت شناسایی </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDIs</span><span style="font-size:12.0pt"><span b="" style="font-family:" zar=""> ، از سه نرم افزار آنلاین دارویی شامل</span></span> <span dir="LTR" new="" roman="" style="font-family:" times="">Medscape</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">، </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">Epocrates</span><span style="font-size:12.0pt"><span b="" style="font-family:" zar=""> و </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">Drugs.com</span> <span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">استفاده گردید. تحلیل داده‏ها با استفاده از نرم‏افزار</span></span> <span dir="LTR" new="" roman="" style="font-family:" times="">SPSS21</span> <span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">انجام شد.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">یافتهها</span></span></b><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> میانه مدت زمان بستری بیماران در بیمارستان 11 روز با دامنه میان</span></span><span dir="LTR" lang="FA" new="" roman="" style="font-family:" times="">‎</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">چارکی (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">IQR</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">) 15 روز (</span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> میانگین و انحراف معیار </span></span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">67/29</span></span><span lang="FA" style="font-size:12.0pt">±</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">11/14 روز) و در بخش مراقبت</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">‎</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">های ویژه (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">ICU</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">) حدود 7 روز و 11 روز (میانگین و انحراف معیار 87/10</span></span><span lang="FA" style="font-size:12.0pt">±</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">32/11 روز) بود. همچنین، میانگین تعداد داروهای مصرفی برای هر بیمار 09/8</span></span><span lang="FA" style="font-size:12.0pt">±</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">08/18 دارو گزارش شد. در این مطالعه، ارتباط معناداری بین تعداد </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDIs</span><span style="font-size:12.0pt"><span b="" style="font-family:" zar=""> و عوامل مختلف مانند مدت زمان بستری در بیمارستان و ICU و تعداد داروهای مصرفی وجود داشت</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">(P<0.001)</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> . همچنین، هیچ ارتباط معناداری بین سن بیماران و </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDIs</span><span style="font-size:12.0pt"><span b="" style="font-family:" zar=""> مشاهده نشد</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">نتیجه</span></span></b><b>‎</b><b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">گیری:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar=""> با آموزش پرسنل درمانی در مورد </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDI</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">های بالقوه و عوارض آن</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">‎‎</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">ها، همچنین جایگزینی داروهای با تداخلات بالا با گزینههای دیگر و استفاده از نرمافزارهای تشخیص تداخل، میتوان بهطور مؤثری از بروز </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">DDI</span><span lang="FA" style="font-size:12.0pt"><span b="" style="font-family:" zar="">ها و آسیب به بیماران جلوگیری کرده و هزینههای درمان را کاهش داد.</span></span></span></span></span></span></span><br>
</div>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background and Aim:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Drug-Drug Interactions (DDIs) can lead to decreased therapeutic efficacy, the occurrence of serious complications, and even mortality in patients. In the intensive care unit (ICU), the likelihood of these interactions increases due to the administration of a greater number of medications. Therefore, the present study aims to investigate the frequency, severity, and risk factors associated with DDIs in hospitalized patients in the ICU</span></span> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">and its results may contribute to improving therapeutic management and reducing complications arising from DDIs.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> This cross-sectional study was conducted on 79 hospitalized patients in the ICUs of Shohadaye Ashayer Hospital in Khorramabad city from March 21, 2021, to June 21, 2021. To identify drug interactions, three online drug databases—Medscape, Epocrates and Drugs.com—were utilized. Data analysis was performed using SPSS version 21.</span></span><span dir="RTL" lang="FA" style="font-size:14.0pt"><span style="font-family:"B Zar""></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Results:</b> The median length of hospital stay was 11 days with interquartile range (IQR) of 15 days (mean ± standard deviation<span dir="RTL" lang="FA" style="font-size:14.0pt"><span b="" style="font-family:" zar="">:</span></span> 14.29 ± 11.67 days). In the intensive care unit (ICU), the median length of hospital stay was approximately 7 days and IQR was 11 days (mean ± standard deviation<span dir="RTL" lang="FA" style="font-size:14.0pt"><span b="" style="font-family:" zar="">:</span></span> 11.32 ± 10.87 days). Also, the mean number of medications used per patient was 18.08 ± 8.09. In this study, there was a significant correlation between the number of DDIs and various factors such as the duration of hospitalization and the ICU and the number of medications consumed (P<0.001). Also, no significant correlation was observed between DDIs and patients' age.</span></span><br>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""> By educating healthcare personnel about potential DDIs and their adverse effects, replacing high-interaction Drugs with alternative options, and utilizing interaction detection software, it is possible to effectively prevent DDIs and harm to patients while reducing treatment costs.</span></span></span></span></span></span></span><br>
تداخل دارویی, بخش مراقبت های ویژه, خطاهای دارویی, Medscape , Epocrates , Drugs.com
drug interaction, intensive care unit, medication errors, Medscape, Epocrates, Drugs.com
77
87
http://sjku.muk.ac.ir/browse.php?a_code=A-10-1815-4&slc_lang=fa&sid=1
Leila
Zarei
لیلا
زارعی
Zarei.L@lums.ac.ir
5400319475328460071516
5400319475328460071516
No
Ali
Kharazmkia
علی
خوارزم کیا
kharazmkia@lums.ac.ir
5400319475328460071517
5400319475328460071517
Yes
Sobhan
Bayat
سبحان
بیات
Bayat.S@lums.ac.ir
5400319475328460071518
0009-0003-5842-0438
No
Hadi
Hayati
هادی
حیاتی
Hayati.H@lums.ac.ir
5400319475328460071519
5400319475328460071519
No