RT - Journal Article T1 - Investigating the Protective Effect of an Interval Training on Neutrophilic Factors of BDNF and CDNF in Rats Fed with High-fat Foods JF - HBI_Journals YR - 2020 JO - HBI_Journals VO - 25 IS - 1 UR - http://sjku.muk.ac.ir/article-1-4622-en.html SP - 1 EP - 11 K1 - BDNF K1 - CDNF K1 - Full-fat diet K1 - Interval training K1 - Rat AB - Background and Aim: Exercise targets the secretion of brain-derived neurotrophic factors and has a major impact on the overall health of the brain. The present study aimed to investigate the protective effect of a period of interval training on neutrophilic factors of BDNF and CDNF in rats fed with high-fat foods. Materials and Methods: In this experimental study, 42 male Wistar rats were randomly divided into 3 groups with same number: normal nutrition, high fat diet, and high fat diet + interval exercise. Interval exercises were performed in the first 3 weeks with low intensity, moderate intensity in week 4, and week of 5-8th at high intensity and 5 days in per week for 8 weeks. After the end of the eighth week, the rats were killed and the levels of the indices studied were evaluated by ELISA assay kits. One-way ANOVA and Bonferroni test were used to analyze of the data. Results: The results showed that after a high-fat diet, there was a significant decrease in plasma levels of BDNF (P = 0.001) and CDNF (P = 0.001) compared to control group. On the other hand, after a period of interval exercise and nutrition, a significant increase was observed in BDNF levels (P= 0.001, P= 0.002) and CDNF (P= 0.001, P= 0.003) respectively, Compared to control and high fat diet groups. Conclusion: These results may indicate the positive role of this type of exercise in preventing and neutralizing the disadvantages of high-fat diet, metabolic diseases, and as well as maintain of brain health. LA eng UL http://sjku.muk.ac.ir/article-1-4622-en.html M3 10.52547/sjku.25.1.1 ER -