%0 Journal Article %A Moghadasi, Mohsen %A Kalantar-Neyestanaki, Davood %A Karami-Zarandi, Morteza %A Rahdar, Hossein Ali %A Jasemi, Seyedesomaye %A Feizabadi, Moammad Mehdi %T Investigation of antimicrobial susceptibility patterns and frequency of bla OXA genes in carbapenem resistant Acinetobacter baumanniistrains %J Scientific Journal of Kurdistan University of Medical Sciences %V 23 %N 5 %U http://sjku.muk.ac.ir/article-1-3791-en.html %R 10.52547/sjku.23.5.108 %D 2018 %K Acinetobacter baumannii, bla OXA genes, carbapenem, %X Bachground and Aim: Acinetobacter baumannii is one of the important caues of nosocomial infection. Resistance to antibiotics specially carbapenem antibiotics is on the increase which can be an alarming sign for healthcare managers and personnel. The aim of this study was to investigate phentypic and genotypic characteristics of carbapenem resistant A. baumannii in the samples obtained from the patients in Imam Khomeini Hospital, Tehran city. Material and Methods: 100 strains were identified as A. baumannii by biochemical tests and molecular methods. Multiplex PCR method was used for identification of the genes of bla OXA family. Drug susceptibility pattern was determined by disk diffusion method. Result: Among 100 isolates, 95(95%) were resistant to carbapenem antibiotics( imipenem and meropenem). PCR method was performed to identify blaOXA family genes. 9 isolates had blaOXA-51 gene while 38 had both blaOXA-51 and blaOXA-23 genes. 20 isolates were positive for blaOXA-51 and blaOXA-24 genes, 6 isolates had blaOXA-51 and blaOXA-58, and 8 isolates had blaOXA-51, blaOXA-24 and blaOXA-23 genes. 7 isolates were positive for blaOXA-51, blaOXA-23 and blaOXA-58. 4 isolates had blaOXA-51and blaOXA-24 and blaOXA-58 genes. We detected blaOXA-51and blaOXA-24 and blaOXA-23 and blaOXA-58 genes in three isolates. Conclusion: According to our results carbapenem resistant Acinetobacter baumannii strains spread increasingly among hospital units. We found that carbapenem resistant Acinetobacter strains with a high resistance rate are common in the hospitals in Iran. %> http://sjku.muk.ac.ir/article-1-3791-en.pdf %P 108-119 %& 108 %! detection of bla OXA genes in carbapenem resistance of Acinetobacter baumannii strains %9 Original Research %L A-10-3088-1 %+ Department of Microbiology, School of Medicine, Tehran University of Medical Sciences,Tehran, Iran %G eng %@ 1560-652X %[ 2018