TY - JOUR T1 - The effects of regular aerobic training and grape seed extract on the cardiovascular risk factors in obese older women TT - تاثیر تمرین منظم هوازی همراه با مصرف عصاره دانه انگور بر عوامل خطرزای قلبی عروقی در زنان سالمند چاق JF - HBI_Journals JO - HBI_Journals VL - 20 IS - 3 UR - http://sjku.muk.ac.ir/article-1-1850-en.html Y1 - 2015 SP - 69 EP - 78 KW - Aerobic exercise KW - Homocysteine KW - Fibrinogen KW - Atherosclerosis KW - Grape Seed Extract. N2 - Background and Aim: Cardiovascular diseases, especially atherosclerosis are the main cause of death worldwide which its prevalence is increasing in Iran as well. The present study examined the effect of grape seed supplement and aerobic activity on cardiovascular risk in elderly women. Materials and Methods: In a double-blind study, 24 obese women (BMI≥30), 55 to 65 years old were randomly divided into two groups of exercise with supplement (12 individuals) and exercise (12 individuals). Aerobic training program was performed 1 hour per session, 3 sessions per week during 8 weeks (with 45 to 55 percent of maximum heart rate). A daily dose of 200 mg grape seed extract was used for 8 weeks in supplement group. Blood samples were collected before and 48 hours after the last session of the study (12h fasting). Dependent t-test and independent t-test were used to compare data before and after the study and for comparison between two groups respectively. Results: Data showed a significant difference in amount of homocysteine, hs-CRP, cholesterol, triglyceride and LDL-C between pretest and posttest of supplement group, while there was no difference in any variable in the control group. Conclusion: According to the present study, 8 weeks aerobic exercise and consumption of grape seed extract can prevent atherosclerosis and improve public health. Also it may control and reduce atherosclerosis in obese individuals. Keywords: Aerobic exercise, Homocysteine, Fibrinogen, Atherosclerosis, Grape Seed Extract. Received: Dec 7, 2014 Accepted: Apr 4, 2015 M3 10.22102/20.3.69 ER -