TY - JOUR T1 - Comparison of the effect of single and multiple-dose methotrexate therapy on tubal patency in women with ectopic pregnancy TT - مقایسه ی تاثیر دوز واحد و چندگانه متوتروکسات در درمان حاملگی نابجا، روی بروز انسداد لوله های رحمی JF - HBI_Journals JO - HBI_Journals VL - 20 IS - 6 UR - http://sjku.muk.ac.ir/article-1-2142-en.html Y1 - 2016 SP - 26 EP - 33 KW - Ectopic pregnancy KW - Tubal obstruction KW - Single-dose methotrexate KW - Multiple dose methotrexates. N2 - Background and Aim: Ectopic pregnancy is one of the leading causes of death among the women of reproductive age. Injection of single or multiple doses of methotrexate can be used as a therapeutic approach. The aim of this study was to compare the effect of single and multiple-doses of methotrexate therapy on the tubal patency in women with ectopic pregnancy. Material and Methods: This was an interventional study and included 80 patients with ectopic pregnancy who had been treated with a single dose or multiple doses of methotrexate. After 3 months of hospitalization and treatment, hysterosalpingography was conducted to assess tubal patency. Data were analyzed using SPSS version 21. Results: The frequencies of ipsilateral tubal obstruction were 12 (30%) and 3 (7.5%) in the patients who had received multiple-doses of methotrexate and single-dose methotrexate respectively. Also, 33 (82.5%) patients in the single-dose methotrexate group and 18 (45%) patients in the multiple-dose methotrexate group did not have bilateral obstruction. There was a significant difference in the frequencies of tubal obstruction between the two groups treated with single and multiple doses of methotrexate (P<0.05). Conclusion: The incidence of tubal obstruction in women with ectopic pregnancy was significantly lower in single-dose methotrexate group compared to multiple dose methotrexate groups. Keywords: Ectopic pregnancy, Tubal obstruction, Single-dose methotrexate, Multiple dose methotrexates. Received: Apr 28, 2015 Accepted: Nov 23, 2015 M3 10.22102/20.6.26 ER -