TY - JOUR JF - HBI_Journals JO - SJKU VL - 22 IS - 4 PY - 2017 Y1 - 2017/9/01 TI - Comparison of antibacterial effects of nanoparticles of magnesium oxide and silicon oxide on methicillin resistant bacteria TT - مقایسه اثر ضد باکتریایی نانواکسید منیزیم و نانوسیلیکون بر روی باکتری های مقاوم به متی سیلین N2 - Background and Aim: Considering bacterial resistance to common antibiotics and the need for new drugs, use of medicinal products manufactured by nano-technology, can be effective in the prevention and treatment of bacterial infections. In this study, we evaluated the sensitivity of Staphylococcus aureus and Salmonella to nanoparticles of magnesium oxide and silicon oxide in vitro. Methods: Staphylococcus intermedius and Methicillin-resistant Staphylococcus aureus and Salmonella typhimurium, Salmonella abourtus were cultured in Mueller Hinton Broth medium. Then different concentrations of the nanoparticles of magnesium oxide and silicon oxide were added to the culture medium. After 24 hours of incubation we measured optical density (OD) by means of ELISA reader. Multi-well plate was used as controls. Using SPSS software data were analyzed by ANOVA and LSD post hock test. Results: Silicon nanoparticles prevented growth of Staphylococcus intermedious, Staphylococcus aureus, Salmonella typhimurium and Salmonella abortus (p<0.0001) in a dose dependent way, but showed no antibacterial effect on Salmonella typhi. Also nanoparticles of magnesium oxide showed antimicrobial effect on the above-mentioned bacteria in a dose-dependent manner (p<0.0001). Conclusion: Silicon oxide and magnesium oxide nanoparticles can be used and evaluated as antibacterial drugs in experimental or clinical infections. Keywords: Nanoparticles of silicon, Magnesium oxide nanoparticle, Antibacterial, Methicillin resistant bacteria. Received: May 23, 2016 Accepted: Dec 21, 2016 SP - 27 EP - 35 AU - Barati, Sara AU - Najafzadehvarzi, Hossein AU - Gharibi, Dariush AD - Department of Pharmacology, Faculty of Medicine, Babol Medical Sciences University, Babol, Iran. KW - Nanoparticles of silicon KW - Magnesium oxide nanoparticle KW - Antibacterial KW - Methicillin resistant bacteria. UR - http://sjku.muk.ac.ir/article-1-3394-en.html DO - 10.22102/22.4.27 ER -