TY - JOUR JF - HBI_Journals JO - SJKU VL - 22 IS - 3 PY - 2017 Y1 - 2017/8/01 TI - The association between RNASEL R462Q polymorphism and prostate cancer TT - ارتباط بین سرطان پروستات با پلی مورفیسم ژن RNASEL جایگاه R462Q N2 - Background and Aim: RNase L is a cytoplasmic enzyme of the innate immune system that destroys RNA viruses and also plays an important role in the apoptosis of different cells. The association of ribonuclease L (RNASEL) gene polymorphisms with susceptibility to prostate cancer in different populations has been reported. In this study, the association of RNase L R462Q single nucleotide polymorphism (SNP) and prostate cancer was investigated in Sanandaj City in Iran. Material and Methods: This case-control study included 61 men with confirmed prostate cancer as our case group and 101 men with benign prostatic hyperplasia (BPH) as control group. The genomic DNA from prostate tissue samples were obtained from both groups and were embedded in paraffin blocks. The prevalence of the polymorphism of RNASEL gene in R462Q location was determined by using Amplification-Refractory Mutation System PCR (ARMS-PCR). Data were analyzed by chi-square test. Results: The mean age was 70.12±13.37 years for the patients with cancer and 71.05±9.26 years for the control group (P=0.6). The frequencies of GG and GA genotypes in the two groups were not different significantly (p>0.05). The frequencies of AA genotype in the patients with cancer and control group were 18.03% and 5.94% respectively (p= 0.02, OR= 3.48, CI: 1.46-15.2). Conclusion: The results of this study indicated that AA genotype polymorphism of RNASEL gene in R462Q location was associated with increased susceptibility to prostate cancer. Keywords: RNASEL, R462Q, Polymorphism, Prostate cancer, Benign Prostatic Hyperplasia. Received: Oct 23, 2016 Accepted: Feb 6, 2017 SP - 94 EP - 101 AU - Rezaee, Mohammad Ali AU - Hossaini, Worya AU - Nikkhoo, Bahram AU - Khodabandeloo, Mazaher AU - Rahmani, Mohammad Reza AD - Zoonoses Research center, Kurdistan University of Medical Sciences, Sanandaj, Iran. KW - RNASEL KW - R462Q KW - Polymorphism KW - Prostate cancer KW - Benign Prostatic Hyperplasia. UR - http://sjku.muk.ac.ir/article-1-3273-en.html DO - 10.22102/22.3.94 ER -