%0 Journal Article %A Modaresi, Mehrdad %A Messripour, Manouchehr %A Asadi marghmaleki, Mehran %T Effect of saffron extract on electrophoretic pattern of serum proteins in the male mice %J Scientific Journal of Kurdistan University of Medical Sciences %V 13 %N 4 %U http://sjku.muk.ac.ir/article-1-97-en.html %R %D 2009 %K Albumin, Globulin, Serum, Mice, Saffron, %X Background and Aim: Due to widespread use of saffron (Crocus sativus L) as food colorant and flavor, and its reputation in folk medicine as a drug, recent studies revealed that main components of saffron are the carotenoids: crocin, crocetin, picrocrocin and safranal which have a large number of physiological effects on different biological systems. Our objective was to assess the efficacy of Crocus sativus on serum proteins pattern in the male mice. Material and Methods: Five groups including eight adult male Balb/C mice were used in this study. Normal saline administered as placebo to control group and saffron extract in doses of 25 mg/Kg/48hr, 50 mg/Kg/48hr, 100 mg/Kg/48hr and 200 mg/Kg/48hr were injected intra peritoneally for 20 days to experimental groups. The levels of Albumin, Alpha-1, Alpha-2, Beta and Gamma globulins were separated electrophoretically and A/G ratio was calculated from the pattern of electrophoretogram. Results: The result indicated that the levels of Albumin increased significantly in two experimental groups that had received 50 mg/Kg/48h and 100 mg/Kg/48h extract of Saffron as compared to the control group, the levels of Alpha-1 didn't have any remarkable changes in any group. The injection of 50 mg/Kg/48h, 100 mg/Kg/48h and 200 mg/Kg/48hr extract of saffron decreased (p %> http://sjku.muk.ac.ir/article-1-97-en.pdf %P 23-29 %& 23 %! Effect of saffron extract on electrophoretic pattern of serum proteins %9 Original Research %L A-10-1-89 %+ %G eng %@ 1560-652X %[ 2009