TY - JOUR T1 - The protective effects of Tanacetum parthenium extract on CCl4-induced myocardium injury in rats TT - بررسی اثرات محافظتی عصاره‌ی بابونه‌ی گاوی بر آسیب‌ قلبی القاء شده توسط تتراکلریدکربن در موش صحرایی JF - HBI_Journals JO - HBI_Journals VL - 23 IS - 2 UR - http://sjku.muk.ac.ir/article-1-4108-en.html Y1 - 2018 SP - 70 EP - 80 KW - Tanacetum parthenium KW - Carbon tetrachloride KW - Myocardium KW - Lipid peroxidation KW - Antioxidant. N2 - Background and Aim: The aim of this study was to investigate the protective effects of Tanacetum parthenium extract (TPE) on lipid peroxidation and acute heart injury induced by carbon tetrachloride (CCl4) in rats. Materials and Methods: In an experimental study, 30 male Wistar rats were divided into 5 groups (n=6). Two of the groups were normal and damage control groups, other 3 groups were damage groups treated with 40, 80 and 120 mg / kg of TPE for 14 days before being damaged by CCl4. At the end of the study we measured the activity of creatine kinase (CK-MB) isoenzyme and lactate dehydrogenase (LDH), total cholesterol (TC), HDL-C and LDL-C in serum, as well as the activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), and arylesterase (ARE) and malondialdehyde (MDA) concentration, as lipid peroxidation index, in myocardial homogenates. Results: The results of this study showed that treatment with carbon tetrachloride significantly increased the levels of CK-MB, LDH, TC, LDL-C and MDA and decreased ARE, HDL-C, SOD and GPX (P <0.001) in a dose dependent manner. Conclusion: The present study demonstrated that TPE can be considered as a substance with various potential effects such as antioxidant activity and cardioprotective effects. Key words: Tanacetum parthenium, Carbon tetrachloride, Myocardium, Lipid peroxidation, Antioxidant. Received: Sep 20, 2017 Accepted: Jan 30, 2018 M3 10.29252/sjku.23.2.70 ER -