AU - Mansouri, Kamran AU - Seifi, Parivash AU - Mostafaie, Ali AU - Mohammadi-Motlagh, Hamid Reza TI - Study of the mechanisms and causes related to angiogenesis PT - JOURNAL ARTICLE TA - HBI_Journals JN - HBI_Journals VO - 17 VI - 2 IP - 2 4099 - http://sjku.muk.ac.ir/article-1-804-en.html 4100 - http://sjku.muk.ac.ir/article-1-804-en.pdf SO - HBI_Journals 2 AB  - Angiogenesis, the process of new blood vessels formation from existing ones, is important for the normal body growth and development. Angiogenesis is dependent on a delicate equilibrium between endogenous angiogenic and anti-angiogenic factors. If this equilibrium is disturbed, different diseases such as corneal neovascularization, endometriosis, obesity, atherosclerosis, diabetic retinopathy, psoriasis, tumor growth and metastasis may ensue. In general, angiogenesis process is under the influence of several factors and consists of cellular events such as migration, proliferation and differentiation of endothelial cells and finally formation, maturation and remodeling of vessels. Hence, angiogenesis inhibition as a useful measure in conventional therapies such as chemotherapy and radiation has attracted scientists’ attention studying on these issues. In recent years, the angiogenesis control has been considered as a novel idea for control and treatment of angiogenesis-dependent disorders especially tumor growth and metastasis. Because of its importance in causing these disorders, we discuss various aspects of angiogenesis, its mechanisms and causes and also the related studies in this review article. CP - IRAN IN - 1. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Department of Molecular Medicine, School of advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran. LG - eng PB - HBI_Journals PG - 96 PT - Original Research YR - 2012