TY - JOUR JF - HBI_Journals JO - SJKU VL - 16 IS - 2 PY - 2011 Y1 - 2011/8/01 TI - Study of expression pattern of eIF4E gene as a molecular marker in thyroid cancer TT - مطالعه بیان ژن EIF4E به عنوان مارکر مولکولی در سرطان تیروئید N2 - ABSTRACT Background and Aim: Regulation of protein synthesis in the early stage of translation depends on the function of eIF4E factor especially in the form of eukaryotic initiation factor (eIF4F). Overexpression of eIF4E in multiple cancer types, including malignancies of the prostate, breast, colon, lung, and the hematopoietic system is indicative of the role of this factor in tumorogenesis and promotion of the cancers. In this study we investigated the expression pattern of eIF4E as a new molecular marker in thyroid tumors and their marginal normal tissues. Materials and Methods: We used semi-quantitative RT-PCR technique to examine the expression of eIF4E in 21 papillary carcinoma tissue specimens and 14 specimens of corresponding marginal normal tissue adjacent to the malignant lesions. ß2m gene was considered as an internal control. Rate of expression of eIF4E in different groups were compared with one another by use of SPSS software and data were analyzed by one way ANOVA and t-test. Results: Our data revealed significant expression of eIF4E in all tumor samples compared to non-tumor lesions and normal tissues (P SP - 16 EP - 26 AU - Hoseinpourfeizi, Mohammad Ali AU - Ghanbarian, Marzieh AU - Khalaj-Kondori, Mohammad AU - Shiri, Soraya AU - Montazeri, Vahid AU - Halimi, Monireh AD - Tabriz University KW - eIF4E KW - semi-quantitative RT-PCR KW - Thyroid cancer KW - Tumor progression. UR - http://sjku.muk.ac.ir/article-1-532-en.html ER -