%0 Journal Article %A Gharib Naseri, M %A Anvari, E %A Badavi, M %T Spasmolytic effect of Cuscuta pentagona fruit aqueous extract on rat ileum %J Scientific Journal of Kurdistan University of Medical Sciences %V 12 %N 2 %U http://sjku.muk.ac.ir/article-1-24-en.html %R %D 2007 %K Key words: Cuscuta pentagona; Rat; Ileum; Contractility; Gastrointestinal transit, Time., %X   ABSTRACT   Background and Aim: Cuscuta pentagona (convolvulaceae) has been used in Iran for gastrointestinal disorders. The aim of the present study was to investigate the effect of Cuscuta pentagona fruit aqueous extract (CPE) on rat ileum contractility.   Materiala and Methods: The fruit extract was prepared according to the traditional method by boiling the fruits in distilled water. Ileum was dissected from adult male Wistar rat, mounted in an organ bath (10 ml) containing Tyrode solution (37ºC, pH 7.4). Ileal contractions were recorded under 1 g initial tension, by an isotonic transducer. In many in-vitro studies, potassium chloride and acetyl cholin induced contractions of rat ileum in the absence or presence of some antagonists had been assessed. In some in vivo studies gastrointestinal transit time in different groups of rats after administration of saline, three doses of fruit extract or atropine, had been measured.   Results: Cumulative concentrations of CPE (0.5-8 mg/ml) reduced the ileal contractions induced by KCl (60 mM) and ACh (1 µM) revealing a dose dependent effect (p %> http://sjku.muk.ac.ir/article-1-24-en.doc %P 0-0 %& 0 %! Spasmolytic effect of Cuscuta pentagona fruit aqueous extract on rat ileum %9 Original Research %L A-10-1-17 %+ %G eng %@ 1560-652X %[ 2007