TY - JOUR T1 - The effect of long term oral administration of Hypericum perforatum aerial part on learning and memory in diabetic rats by means of passive avoidance test TT - بررسی اثر تجویز خوراکی و دراز مدت بخش هوایی علف چای بر یادگیری و حافظه در موش صحرایی دیابتی با استفاده از آزمون اجتنابی غیرفعال JF - HBI_Journals JO - HBI_Journals VL - 11 IS - 1 UR - http://sjku.muk.ac.ir/article-1-178-en.html Y1 - 2006 SP - 1 EP - 10 KW - Hypericum perforatum KW - Learning and memory KW - Passive avoidance test KW - Diabetes mellitus KW - Streptozotocin KW - Rat N2 - ABSTRACT Background and Aim: Diabetes mellitus (especially type I) is accompanied with disturbances in learning, memory, and cognitive skills in the human beings and experimental animals. Considering the potential nootropic effect of the medicinal plant Hypericum perforatum (HP), therefore, this study was conducted to evaluate the effect of long term oral administration of HP aerial part on learning and memory in diabetic rats by use of passive avoidance test. Materials and Methods: In this study, male Wistar diabetic rats were randomly divided into control, HP-treated control, diabetic, and HP-treated diabetic groups. HP treatment continued for 1 to 2 months. For induction of diabetes a single dose of streptozotocin 60mg/kg was injected i.p. Serum glucose level was determined before the study and at the 4th and 8th weeks after the experiment. In addition, for evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined after 1 and 2 months using passive avoidance test. Results: One- and two-month administration of HP aerial part at a weight ratio of 1/15 did not show any significant hypoglycemic effect in treated control and diabetic groups. Furthermore, there was a significant increase (p M3 ER -