:: Volume 28, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2024) ::
SJKU 2024, 28(6): 123-145 Back to browse issues page
Relationship between Oral-Dental Health Status with Chronic Systemic Diseases and Salivary IgA Level in Elderly Population: A Systematic Review
Parand Pourghane1 , Parand Pourghane1 , Arash Pourgholaminejad 2
1- Department of Nursing, Zeynab (P.B.U.H) School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Medical Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran , arash_pgn@yahoo.com
Abstract:   (927 Views)
Background and Aim: The importance of oral and dental health is more in the elderly than other age groups and various factors can affect it. The aim of this study was to investigate the relationship of oral and dental health in the elderly with the amount of salivary immunoglobulin-A (IgA), the presence of chronic and systemic diseases, and some demographic indicators such as age, gender, residential place, marital status, economic status, compliance with oral and dental hygiene, smoking and educational level. It seems that the aforementioned factors are related to the oral and dental health of the elderly.
Materials and Methods: In this systematic review we searched Google Scholar, Scopus, PubMed and SID databases for Persin and English articles between 2010 and 2020. Finally, 19 articles were selected.
Results: Based on our literature review, it seems that the presence of age-related diseases, whether chronic or systemic can influence the oral and dental health. Moreover, increased salivary IgA levels could be directly associated with oral and dental problems. Some other factors including better economic status and maintenance of oral and dental health can be related to the improvement of the oral health specially in the elderly. Although, higher education level, city of residence, lack of smoking habit, gender and marital status did not  show definite effects on maintaining oral- dental health, but can affect this process.
Conclusion: Consequently, self-care educations for maintaining the oral-dental health and also follow up of the old patients with chronic systemic diseases had positive effects on the improvement of the oral and dental health.

Keywords: Oral health, Dental health, Elderly, Salivary IgA, Chronic disease, Systemic disease
Full-Text [PDF 554 kb]   (157 Downloads)    
Type of Study: Review | Subject: Immunology
Received: 2021/10/29 | Accepted: 2022/10/24 | Published: 2024/02/6
1. 1.Wong FM, Ng YT, Leung WK. Oral Health and Its Associated Factors Among Older Institutionalized Residents-A Systematic Review. International journal of environmental research public health. 2019;16(21):4132. [DOI:10.3390/ijerph16214132] [PMID] []
2. Kailembo A, Preet R, Williams JS. Socioeconomic inequality in self-reported unmet need for oral health services in adults aged 50 years and over in China, Ghana, and India. International journal for equity in health. 2018;17(1):99. [DOI:10.1186/s12939-018-0812-2] [PMID] []
3. Koistinen S, Olai L, Ståhlnacke K, Fält A, Ehrenberg A. Oral health‐related quality of life and associated factors among older people in short‐term care. International journal of dental hygiene. 2020;18(2):163-72. [DOI:10.1111/idh.12424] [PMID] []
4. Koistinen S, Olai L, Ståhlnacke K, Fält A, Ehrenberg A. Oral health and oral care in short‐term care: prevalence, related factors and coherence between older peoples' and professionals' assessments. Scandinavian journal of caring sciences. 2019;33(3):712-22. [DOI:10.1111/scs.12667] [PMID] []
5. Sato M, Sugimoto M, Yamamoto Y, Saruta J, Tsukinoki K. Effect of oral functional training on immunological abilities of older people: a case control study. BMC oral health. 2018;18(1):1-9. [DOI:10.1186/s12903-017-0461-7] [PMID] []
6. Sistig S, Vučićević,Boras V, Lukač J, Kusić Z. Salivary IgA and IgG subclasses in oral mucosal diseases. Oral diseases. 2002;8(6):282-6. [DOI:10.1034/j.1601-0825.2002.20844.x] [PMID]
7. Millet N, Solis NV, Swidergall M. Mucosal IgA prevents commensal Candida albicans dysbiosis in the oral cavity. Frontiers in Immunology. 2020;11:2448. [DOI:10.3389/fimmu.2020.555363] [PMID] []
8. Saravani S, Kadeh H, Arbabi S. Oral and Dental Status, Oral Health-Related Quality of Life and Associated Factors among Institutionalized Elderly in Southeast Iran-A Cross Sectional Study. Journal of Dental Materials Techniques. 2020;9(4):176-84.
9. Rabiei M, Shakiba M, Vanobbergen JJJoD. Oral and Systemic Conditions in Elderly Population Groups in Talash, North of Iran. 2013;2(1):18-21. [DOI:10.18869/acadpub.3dj.2.1.3]
10. Khosrozadeh H, Alavi N, Gilasi H, Izadi M. Oral health-related quality of life in older people in Kashan/Iran 2015. Nursing Midwifery Studies. 2017;6(4):182-8. [DOI:10.4103/nms.nms_55_17]
11. Owlia F, Bahadori L, Ahadian H, Hakimian R, Kazemeini SK. Prevalence of Chronic Diseases in Elderly Living in Yazd Nursing Homes, and Its Relations with Oral Soft Tissue Lesions (OSTL). Journal of Community Health Research. 2019;8(4):196-202. [DOI:10.18502/jchr.v8i3.1565]
12. Motallebnejad M, Mehdizadeh S, Najafi N, Sayyadi F. The evaluation of oral health-related factors on the quality of life of the elderly in Babol. Contemporary clinical dentistry. 2015;6(3):313-317. [DOI:10.4103/0976-237X.161867] [PMID] []
13. Haeri-Araghi H, Zarabadipour M, Safarzadeh-Khosroshahi S, Mirzadeh M. Evaluating the relationship between dental caries number and salivary level of IgA in adults. Journal of clinical and experimental dentistry. 2018;10(1):e66. [DOI:10.4317/jced.54271] [PMID] []
14. Badabaan GM, Arafa AA. The Relationship between Salivary IgA Level and Dental Caries in Healthy School-Aged Children in Makkah Al-Mukarramah. Int J Health Sci Res. 2017;7(6):125-34.
15. Ahmadi A, Sahaf R, Rashedi V, Akbari Kamrani AA, Shati M, Delbari A. Relationship Between Oral Health and Demographic Characteristics in Retired Elderly People in Iran. Salmand: Iranian Journal of Ageing. 2019;13(4):452-63. [DOI:10.32598/SIJA.13.4.452]
16. Rashidi-Maybodi F, Haerian-Ardakani A, Zarabadi Pour M, Heydari-Postakan R, Pourbaferani H. Evaluation of Oral Health of Elderly Patients Referring to Khatam ol Anbia Clinic in Yazd in 2014 %J Journal of Health. 2016;7(2):227-35.
17. Balanian S, Mirzaee M, Jambarsang S, Hosseini SAS. Oral health of elderly people in Yazd city and its relationship with quality of life. Journal of Dental Medicine. 2019;32(3):171-6.
18. Khatmi Nasab N, Shamshiri M, Zamani U. The Study of Oral Health Status and Its Related Quality of Life in Elderly People Supported by Welfare Organization in Ardabil City. Journal of Health and Care. 2019;21(4):308-18. [DOI:10.29252/jhc.21.4.308]
19. Faezi M, Rejeh N, Soukoti M. Assessment of oral health in older people referred to selected dentistry schools of universities of Tehran %J Journal of Health Promotion Management. 2015;5(1):1-10.
20. Esfahanizadeh N, Farajollahi S, Hajmaleki Z, Daneshparvar N. Evaluation of the periodontal status among the institutionalized Iranian elderly supervised by Behzisti Organization in Tehran (2011) %J journal of research in dental sciences. 2013;10(3):199-204.
21. Kosari M, Hoseini Z, Golrizi F. The investigation of oral and dental status and its related factors in the elderly in Torbat Heydariyeh in 2015 %J Journal of Torbat Heydariyeh University of Medical Sciences. 2016;4(2):39-44.
22. Rayani A, Zamanzadeh M, Roumani FK. Prevalence of Oral Mucosal Lesions and Related Risk Factors in Elderly People Residing in Nursing Homes in Bandar Abbas in 2018 %J Journal of Mashhad Dental School. 2020;44(2):149-56.
23. Aghili H, Ahadian H, Baghiani Moghaddam MH. Dental health and treatment needs of elderly home residents and nonresidents in Yazd city. Health System Research. 2010;6(1):116-22.
24. Rabiei M, Shakiba M, Masoudirad H, Javadinia A. Dental status among urban and rural elderly of Talesh (2009) %J Journal of Inflammatory Diseases. 2011;15(3):69-75.
25. Farokhnezhad Afshar P, Malakouti SK, Ajri-Khameslou M. How was the oral health of the older people in Tehran's Parks in 1396? %J Journal of Gerontology. 2018;2(3):57-63. [DOI:10.29252/joge.2.3.57]
26. Mohammad Hossein Hajiebrahimi, Abdolrahman Charkazi, Babak Rastgarimehr, Anahita Homayonpour, Zahra Hajiebrahimi, Morteza Mansourian, et al. ORAL HEALTH SITUATION IN ELDER PEOPLE IN GORGAN CITY, 2009 %J Iranian Journal of Diabetes and Lipid Disorders. 2014;13(6):505-12.
27. Rabiei M, Shakiba M, Vanobbergen J. Oral and Systemic Conditions in Elderly Population Groups in Talash, North of Iran. Journal of Dentomaxillofacial. 2013;2(1):18-21. [DOI:10.18869/acadpub.3dj.2.1.3]
28. Kobrai-Abkenar F, Pourghane P, Jafarzadeh-Kenarsari F, Roushan ZA, Edvardsson D. Psychometric properties of the Persian language person-centered climate questionnaire-Patient version (PCQ-P). Heliyon. 2020;6(10):e05154. [DOI:10.1016/j.heliyon.2020.e05154] [PMID] []
29. Tahmasebinia F, Pourgholaminejad A. The role of Th17 cells in auto-inflammatory neurological disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017;79:408-16. [DOI:10.1016/j.pnpbp.2017.07.023] [PMID]
30. Pourgholaminejad A, Tahmasebinia F. The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory Disorders. Neuroimmune Diseases: Springer; 2019. p. 83-107. [DOI:10.1007/978-3-030-19515-1_3]
31. Blutt SE, Miller AD, Salmon SL, Metzger DW, Conner ME. IgA is important for clearance and critical for protection from rotavirus infection. Mucosal immunology. 2012;5(6):712-9. [DOI:10.1038/mi.2012.51] [PMID] []
32. Challacombe S, Percival R, Marsh P. Age‐related changes in immunoglobulin isotypes in whole and parotid saliva and serum in healthy individuals. Oral microbiology and immunology. 1995;10(4):202-7. [DOI:10.1111/j.1399-302X.1995.tb00143.x] [PMID]
33. Khan SF, Katti G, Baba I, Khan N. Age-related changes of salivary IgA among healthy subjects. Journal of Indian Academy of Oral Medicine and Radiology. 2015;27(2):203-206. [DOI:10.4103/0972-1363.170138]
34. Gómez SI, Jaramillo LM, Moreno GC, Roa NS, Rodríguez A. Differential reactivity of salivary IgA and IgG against Streptococcus mutans proteins in humans with different caries experience. Acta Odontologica Latinoamericana. 2015;28(1):3-12.
35. Ranadheer E, Nayak UA, Reddy NV, Rao VAP. The relationship between salivary IgA levels and dental caries in children. Journal of Indian Society of Pedodontics and Preventive Dentistry. 2011;29(2):106-112. [DOI:10.4103/0970-4388.84681] [PMID]
36. Shifa S, Muthu M, Amarlal D, Prabhu VR. Quantitative assessment of IgA levels in the unstimulated whole saliva of caries-free and caries-active children. Journal of Indian Society of Pedodontics and Preventive Dentistry. 2008;26(4):158-161. [DOI:10.4103/0970-4388.44031] [PMID]
37. Kuriakose S, Sundaresan C, Mathai V, Khosla E, Gaffoor F. A comparative study of salivary buffering capacity, flow rate, resting pH, and salivary Immunoglobulin A in children with rampant caries and caries-resistant children. Journal of Indian Society of Pedodontics and Preventive Dentistry. 2013;31(2):69 [DOI:10.4103/0970-4388.115697] [PMID]
38. Mendonça FHBP, Santos SSFd, Faria IdSd, Gonçalves e Silva CR, Jorge AOC, Leão MVP. Effects of probiotic bacteria on Candida presence and IgA anti-Candida in the oral cavity of elderly. Brazilian dental journal. 2012;23(5):534-8. [DOI:10.1590/S0103-64402012000500011] [PMID]
39. POUR eSLAMI H, Moshtaghi G, Hori A, SHarifi M, Ziaaddini H. Comparison of salivary secretory IGA in caries-free children and children with severe early childhood caries. Journal of Kerman University of Medical Sciences. 2011;17(1):83-8.
40. Jafarzadeh A, Sadeghi M, Karam GA, Vazirinejad R. Salivary IgA and IgE levels in healthy subjects: relation to age and gender. Brazilian oral research. 2010;24(1):21-7. [DOI:10.1590/S1806-83242010000100004] [PMID]

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Volume 28, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2024) Back to browse issues page